Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Colorectal cancer is common among obese individuals. The purpose of the current study was to determine changes in DNA methylation status and mRNA expression of thyroid hormone receptor beta (THRB), as a tumor suppressor, and thyroid hormone inactivating enzyme, type 3 deiodinase (DIO3) genes, in human epithelial colon tissues of healthy obese individuals.
Methods: Colon biopsies were analyzed by methylation sensitive-high resolution melting (MS-HRM) to investigate promoter methylation of DIO3 and THRB, and by quantitative real-time polymerase chain reaction to assay expression of DIO3 and THRB mRNA on eighteen obese and twenty-one normal-weight healthy men.
Results: There was no significant difference in mean methylation levels at the THRB promoter region between the two groups. Nevertheless, obesity decreased THRB expression levels, significantly (P < 0.05; fold change: 0.19). Furthermore, obesity attenuated DNA methylation (P < 0.001) and enhanced mRNA expression of DIO3 (P < 0.05; fold change: 3).
Conclusions: Our findings suggest that obesity may alter expression of THRB and DIO3 genes through epigenetic mechanism. Alterations of THRB and DIO3 expressions may predispose colon epithelium of obese patients to neoplastic transformation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9628115 | PMC |
| http://dx.doi.org/10.1186/s12920-022-01387-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Assessing thyroid peroxidase antibodies in Emirati medical students: a cross-sectional pilot study.
Front Endocrinol (Lausanne)
September 2025
Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Introduction: Anti-thyroid peroxidase antibodies (TPO-Ab) are detectable in almost all patients with autoimmune thyroid disease or Hashimoto's thyroiditis (HT) but may also be present in healthy individuals. HT affects women to a greater extent than men and can lead to overt hypothyroidism, which may increase the risk of miscarriage. There are no local data available on the prevalence of TPO-Ab among healthy women in the United Arab Emirates.
View Article and Find Full Text PDFCase Report: Ectopic CRH production by adrenal adenoma as a unique cause of the ACTH-dependent Cushing's syndrome.
Front Endocrinol (Lausanne)
September 2025
Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Isolated ectopic secretion of corticotropin-releasing hormone (CRH) is an exceedingly rare cause of Cushing's syndrome (CS), accounting for fewer than 1% of cases. Ectopic CS is an uncommon but potentially life-threatening condition that often necessitates urgent diagnostic evaluation and treatment. Hormonal testing may suggest a pituitary origin, complicating the diagnostic process.
View Article and Find Full Text PDFAn investigation of the pattern and mechanism of comorbidity in patients with Hashimoto's thyroiditis.
Front Endocrinol (Lausanne)
September 2025
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Objective: This study aimed to investigate comorbidity patterns and potential pathogenic mechanisms in patients with Hashimoto's thyroiditis (HT).
Methods: Patients with HT who visited the outpatient clinic of the Thyroid Department at Dongzhimen Hospital, Beijing University of Chinese Medicine, between June 2021 and December 2024 were included. Association rule analysis and logistic regression analysis were performed using SPSS 25.
Hürthle Cell Carcinoma Arising in a Thyroglossal Duct Cyst.
Indian J Nucl Med
August 2025
Department of Nuclear Medicine, Mohammed V Military Teaching Hospital, Rabat, Morocco.
Thyroglossal duct carcinoma is a rare clinical condition, accounting for only 1% of operated cases. It is characterized by ectopic thyroid adenocarcinoma developing within thyroglossal duct cysts (TGDCs). Among these, papillary thyroid carcinoma is the most frequently reported pathological type.
View Article and Find Full Text PDFInvolvement of the PI3K/Nrf2 Pathway in Arsenic-Induced Endocrine and Thyroid Toxicity in Rats.
J Appl Toxicol
September 2025
School of Public Health, Key Laboratory of Special Environmental and Health Research, Xinjiang Medical University, Urumqi, China.
Humans' exposure to arsenic (As) has been associated with the development of various diseases. Some health effects may be mediated by arsenic-induced toxicity to the thyroid and endocrine systems, but its underlying mechanisms remain unclear. The overall aim of our study was focused on using sodium arsenite (NaAsO)-exposed rats to investigate the involvement of the phosphatidylinositol 3-kinase (PI3K) and transcription factor NF-E2-related factor 2 (Nrf2) pathways in toxicity to the thyroid and endocrine systems.
View Article and Find Full Text PDF