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Article Abstract
Berberine and berbamine are bioactive compounds of benzylisoquinoline alkaloids (BIAs) present in species. The contents of berbamine are 20 times higher than berberine in leaf tissues in three closely related species: and . This is the first report on the quantification of berberine compared to the berbamine in the species. Comparative transcriptome analyses were carried out with mRNAs from the leaf tissues of the three-species. The comparison of the transcriptomes of and to those of showed a consistently higher number of differentially expressed genes than in KEGG and DEG analyses. All genes encoding enzymes involved in berberine synthesis were identified and their expressions were variable among the three species. There was a single copy of CYP80A/berbamunine synthase in . Methyltransferases and cytochrome P450 mono-oxidases (CYPs) are key enzymes for BIA biosynthesis. The current report contains the copy numbers and other genomic characteristics of the methyltransferases and CYPs in species. Thus, the contents of the current research are valuable for molecular characterization for the medicinal utilization of the species.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610958 | PMC |
| http://dx.doi.org/10.3390/plants11202676 | DOI Listing |
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