miR-24-2 targets Akt and inhibits cell survival, EMT, and tumour growth in triple-negative breast cancer.

Background: Breast cancer is one of the most common types of cancer in the world, and triple-negative breast cancer (TNBC) is an extremely aggressive subtype. This study aimed to investigate the efficacy and mechanisms of miR-24-2 against TNBC.

Methods: MDA-MB-231 (TNBC), HEK293T and HEK293 cells were used for various assays including cell viability and proliferation, cell migration, and invasion.

Chemical composition, antioxidant, antimicrobial, and anticancer activities of Mahonia napaulensis DC. bark from Nepal.

Background: Cancer is one of the major health problems worldwide and medicinal plants constitute a common alternative for cancer treatment having no or fewer side effects. This study aimed to assess total phenolic (TPC) and flavonoid (TFC) contents, antioxidant, biological activities (especially antibacterial, antifungal, and anticancer), and chemical composition of methanol extract of M. napaulensis DC.

Polydatin inhibits histone deacetylase 1 and shows an anti-angiogenic action in head and neck squamous cell carcinoma.

Polydatin, a natural derivative of resveratrol, has shown many anticancer properties. However, the underlying mechanisms of its anticancer properties including its effect on the epigenetic landscape are not well understood. Here, we explored the effect of polydatin on histone deacetylase 1 (HDAC1) activity.