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http://dx.doi.org/10.1097/pq9.0000000000000603 | DOI Listing |
JAMA Intern Med
September 2025
Bayer CC AG, Basel, Switzerland.
Importance: There is an unmet need for long-term, safe, effective, and hormone-free treatments for menopausal symptoms, including vasomotor symptoms (VMS) and sleep disturbances.
Objective: To evaluate the 52-week efficacy and safety of elinzanetant, a dual neurokinin-targeted therapy, for treating moderate to severe VMS associated with menopause.
Design, Setting, And Participants: OASIS-3 was a double-blind, placebo-controlled, randomized phase 3 clinical trial that was conducted at 83 sites in North America and Europe from August 27, 2021, to February 12, 2024, and included postmenopausal women aged 40 to 65 years who were seeking treatment for moderate to severe VMS (no requirement for a minimum number of VMS events per week).
Pediatr Surg Int
September 2025
Department of Pediatric Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Purpose: The timing of elective surgery for asymptomatic congenital pulmonary airway malformation (CPAM) at birth remains controversial. We aimed to describe characteristics and outcomes of patients who underwent surgery for CPAM.
Methods: We retrospectively identified patients aged < 18 years who were hospitalized for CPAM during the neonatal period and underwent surgery between July 2010 and March 2022 using the Diagnosis Procedure Combination database in Japan.
Paediatr Anaesth
October 2025
Human Anatomy and Embryology Unit, Faculty of Medicine and Health Sciences, Universitat of Barcelona, Barcelona, Spain.
The costoclavicular brachial plexus block has gained relevance as a safe and effective regional anesthesia technique for upper limb orthopedic surgery in adults, but data in pediatric populations remain limited. This study aimed to evaluate the incidence of phrenic nerve palsy associated with CBPB in pediatric patients. We conducted a descriptive observational study in 30 children undergoing upper limb orthopedic surgery.
View Article and Find Full Text PDFPhys Occup Ther Pediatr
September 2025
School of Rehabilitation Therapy, Department of Pediatrics, Queen's University, Kingston, ON, Canada.
Aim: To explore oral feeding management practices, specifically initiation and advancement of oral feeds, across level II and III neonatal intensive care units (NICUs) in Canada.
Methods: A national online survey was conducted across 65 NICUs (34 level II, 31 level III), which included questions on hospital demographics and clinical approaches for initiating, advancing, and managing oral feeds. A descriptive analysis was performed on the responses.
Clin Exp Dent Res
October 2025
Department of Legal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
Objectives: This study was performed to identify the characteristics of oral and maxillofacial injuries in children and determine factors influencing a treatment duration of more than 1 month using medical records.
Material And Methods: This retrospective observational study reviewed medical records of 258 children (< 16 years of age) with maxillofacial trauma treated at a university hospital between 2011 and 2021. Patients with and without tooth fractures or dislocations were compared, and the prevalence of injuries was analyzed across three age groups (0-2, 3-5, ≥ 6 years).