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Junior investigators from groups underrepresented in the biomedical workforce confront challenges as they navigate the ranks of academic research careers. Biochemical research needs the participation of these researchers to adequately tackle critical research priorities such as cardiovascular health disparities and health inequities. We explore the inadequate representation of underrepresented minority investigators and the historical role of systemic racism in impacting their poor career progression. We highlight challenges these investigators face, and opportunities to address these barriers are identified. Ensuring adequate recruitment and promotion of underrepresented biomedical researchers fosters inclusive excellence and augments efforts to address health inequities. The Programs to Increase Diversity among Individuals Engaged in Health-Related Research (PRIDE), funded by the National Heart, Lung, and Blood Institute (NHLBI), is a pilot program by the National Institutes of Health (NIH) that aims to address these challenges yet, only a limited number of URM can be accepted to PRIDE programs. Hence the need for additional funding for more PRIDE or PRIDE-like programs. Here we aim to examine the challenges underrepresented minority biomedical investigators face and describe ongoing initiatives to increase URM in biomedical research using the NHLBI-PRIDE program as a focus point.
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http://dx.doi.org/10.1016/j.jnma.2022.09.007 | DOI Listing |
JCO Glob Oncol
May 2025
Grupo Oncoclínicas, São Paulo, Brazil.
Head and neck squamous cell carcinoma (HNSCC) represents a significant public health burden in developing countries, where access to early diagnosis, comprehensive care, and research infrastructure is limited. This article synthesizes the insights generated during a Fireside Chat convened by members of the Latin American Cooperative Oncology Group (LACOG)-Head and Neck and the Brazilian Group of Head and Neck Cancer (GBCP), with the participation of international expert Professor Hisham Mehanna. The discussion addressed key challenges and opportunities in clinical and translational research within resource-constrained settings.
View Article and Find Full Text PDFToxicon
September 2025
Grupo Infección e Inmunidad, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira, Colombia. Electronic address:
Scorpion venom is a complex biochemical arsenal with significant ecological and biomedical importance. Advances in transcriptomic techniques have provided valuable insights into the composition and functional diversity of venoms. This systematic review analyzes transcriptomic research conducted between 2010 and 2024, focusing on methodologies such as Expressed Sequence Tags (ESTs) and Next-Generation Sequencing (NGS).
View Article and Find Full Text PDFAdv Mater
September 2025
Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
In both native and engineered tissues, the extracellular matrix (ECM) supports and regulates nearly all aspects of cellular pathophysiology, and in response, cells extensively remodel their surrounding extracellular environments through new ECM protein deposition. Understanding this intricate bi-directional cell-ECM interaction is key to tissue engineering, but it remains challenging to investigate. This is partly due to the limited sensitivity of conventional proteomics to capture low-abundance newly synthesized ECM (newsECM).
View Article and Find Full Text PDFJ Dairy Sci
September 2025
Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan. Electronic address:
Human milk oligosaccharides (HMO) play crucial roles in establishing a healthy gut microbiota in breastfed infants. Many studies have been conducted using samples collected in different areas with varying lifestyles to examine the relationships between milk HMO, infant gut microbiota, and microbial HMO consumption in feces. The present study analyzed the tripartite relationship using samples obtained from Mongolian mothers and infants living in herder and urban environments, a population underrepresented in previous research.
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