Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Non-secretory multiple myeloma (MM) is a rare condition that accounts for only 3% of MM cases and is defined by normal serum and urine immunofixation and a normal serum free light chain ratio. Non-secretory MM with multiple extramedullary plasmacytomas derived from endobronchial lesions is extremely rare and can be misdiagnosed as metastasis of solid cancer.
Case Summary: A 36-year-old man presented with progressive facial swelling and nasal congestion with cough. Various imaging studies revealed an endobronchial mass in the left bronchus and a large left maxillary mass with multiple destructive bone metastatic lesions. He initially presented with lung cancer and multiple metastases. However, pathologic reports showed multiple extramedullary plasmacytomas in the left maxilla and the left bronchus. There was no change in the serum and urine monoclonal protein levels, and no abnormalities were observed in laboratory examinations, including hemoglobin, calcium, and creatinine levels. The bone marrow was hypercellular, with 13.49% plasma cells. The patient was diagnosed with non-secretory MM expressed as multiple extramedullary plasmacytomas with endobronchial lesions in a rare location. Radiation therapy for symptomatic lesions with high-dose dexamethasone was started, and the size of the left maxillary sinus lesion dramatically decreased. In the future, chemotherapy will be administered to control lesions in other areas.
Conclusion: We present a rare case of non-secretory MM with multiple extramedullary plasmacytoma with an endobronchial lesion.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372843 | PMC |
| http://dx.doi.org/10.12998/wjcc.v10.i22.7899 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Extramedullary relapse of acute lymphoblastic leukemia treated with a CAR-T cell therapy bridge to unrelated cord blood transplantation: a case report and review of the literature.
Front Oncol
August 2025
Division of Hematology, Department of Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Extramedullary relapse of acute lymphoblastic leukemia (ALL) is usually associated with poor prognosis. Chimeric antigen receptor T cell (CAR-T cell) therapy followed by allogeneic hematopoietic stem cell transplantation is beneficial for relapsed/refractory (r/r) B cell acute lymphoblastic leukemia (B-ALL). Here, we report a B-ALL patient with extramedullary relapse involving several organs, including multiple lymph nodes and the breast, kidney, uterus and pancreas.
View Article and Find Full Text PDFFatigue as main symptom in an elderly multiple myeloma patient: a Case Report.
Front Med (Lausanne)
August 2025
Department of General Medicine Practice, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Introduction: The high prevalence of fatigue as an atypical clinical manifestation in general practice creates notable diagnostic challenges, particularly in geriatric patients.
Methods: We describe a case of an 80-year-old female presenting with fatigue, initially attributed to poorly controlled diabetes mellitus or upper respiratory infection, who was ultimately diagnosed with multiple myeloma after admitted to the Department of General Medicine at a general hospital. Initial diagnostic workup including physical examination revealed the presence of anterior thoracic mass with undetermined etiology.
Background: Relapsed/refractory multiple myeloma (RRMM) remains difficult to treat despite advances in therapy. B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell (CAR-T) therapies, such as idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel), have improved outcomes, yet many patients relapse within a year. Current International Myeloma Working Group (IMWG) criteria for deep response require prolonged observation.
View Article and Find Full Text PDFMultifocal Colonic Masses as a Presentation of Secondary Extramedullary Plasmacytoma in Relapsing-Refractory Multiple Myeloma: A Case Report and Review of Literature.
JGH Open
September 2025
Division of Digestive Health and Liver Diseases, Department of Medicine Miller School of Medicine at the University of Miami Miami Florida USA.
Background: Multiple myeloma (MM) is a common plasma cell malignancy; however, extramedullary multiple myeloma (EMM) is an aggressive phenotype in which malignant plasma cells proliferate outside of the bone marrow.
Aims: Extramedullary plasmacytomas (EMP) are uncommon and gastrointestinal involvement is exceedingly rare.
Case Presentation: Here, we present a case of multifocal secondary colonic EMP in a patient with relapsed refractory multiple myeloma (RRMM) and review literature demonstrating other cases of secondary colonic EMP.
Solitary extramedullary plasmacytoma mimicking ocular surface squamous neoplasia in an elderly male: A case report.
World J Clin Cases
September 2025
Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneshwar 751019, Odisha, India.
Background: Conjunctival plasmacytoma is an exceedingly uncommon form of extramedullary manifestation of multiple myeloma, with only a handful of cases reported so far.
Case Summary: A 66-year-old male of Indian origin with multiple myeloma presented with a 1-year history of progressive pink mass associated with itching in his left eye. Examination revealed a pinkish conjunctival mass with telangiectasia extending up to the temporal limbus, mimicking ocular surface squamous neoplasia.