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Background: An electrical injury can cause multiple consequences, especially to the nervous system, both peripheral and central. Such consequences may present immediately as well as later on.
Aims Of The Study: To report on a case of a 5-year-old boy with focal refractory status epilepticus after an electrical injury.
Methods: Clinical history, electroencephalography, neuroimaging, and laboratory data of a patient admitted to our emergency department.
Results: A 5-year-old male received an electrical shock by contact with an alternating current source after coming out of the pool. When reaching our emergency department, focal seizures was observed in the same site affected by the electrical insult, with progressive structural changes in the related brain area. In the days after, his neurological conditions dramatically evolved leading to brain death.
Conclusions: Based on our knowledge, this is the first report on refractory status epilepticus in a child after electrical injury. The possible underlying pathogenetic mechanisms are not yet clear.
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http://dx.doi.org/10.1016/j.braindev.2022.08.007 | DOI Listing |
Adv Sci (Weinh)
September 2025
Department of Bioengineering, Yildiz Technical University, Istanbul, 34722, Turkey.
Conductive nanocomposite hydrogels (CNHs) represent a promising tool in neural tissue engineering, offering tailored electroactive microenvironments to address the complex challenges of neural repair. This systematic scoping review, conducted in accordance with PRISMA-ScR guidelines, synthesizes recent advancements in CNH design, functionality, and therapeutic efficacy for central and peripheral nervous system (CNS and PNS) applications. The analysis of 125 studies reveals a growing emphasis on multifunctional materials, with carbon-based nanomaterials (CNTs, graphene derivatives; 36.
View Article and Find Full Text PDFFront Cardiovasc Med
August 2025
Department of Ultrasonic Medicine, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Gap junctions (GJs) are critical structures for cardiac electrical signal conduction and synchronized contraction. Their fundamental components are transmembrane proteins from the connexin (Cx) family, which assemble into hexameric channels to form intercellular ion-permeable pathways, ensuring efficient electrical transmission and coordinated contraction between cardiac cells. Connexin 43 (Cx43), the most abundant connexin in the heart, serves as the primary constituent of ventricular gap junctions.
View Article and Find Full Text PDFCureus
September 2025
Rheumatology, University Hospitals Coventry & Warwickshire, Coventry, GBR.
Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition that may develop after fractures, surgery, or soft tissue trauma. It is characterized by pain disproportionate to the initial injury, often accompanied by sensory, motor, autonomic, and trophic changes. Despite extensive research, pathophysiology remains unclear, and treatment approaches are varied, with inconsistent supporting evidence.
View Article and Find Full Text PDFFront Physiol
August 2025
Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Sciatica, often resulting from lumbar disc herniation or nerve compression, disrupts electrical signal transmission, leading to muscle atrophy, mitochondrial dysfunction, and impaired energy metabolism. This study explored the therapeutic effects of Fu's subcutaneous needling (FSN) in a chronic constriction injury (CCI) rat model, assessing its impact on neuropathic pain, muscle mass, and structural integrity. Histological and ultrastructural analyses demonstrated that FSN alleviated hypersensitivity, reduced muscle atrophy, preserved mitochondrial density, and maintained glycogen storage.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Scool of Disaster and Emergency Medicine, Tianjin University, Tianjin 300072.
Cardiac arrest (CA) is a critical condition in the field of cardiovascular medicine. Despite successful resuscitation, patients continue to have a high mortality rate, largely due to post CA syndrome (PCAS). However, the injury and pathophysiological mechanisms underlying PCAS remain unclear.
View Article and Find Full Text PDF