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Article Abstract
Purpose: To investigate the dose-effect relationship between the dose-volume parameters of residual gross tumor volume (GTV) and clinical prognosis in MRI image-guided adaptive brachytherapy (IGABT) of patients with locally advanced cervical cancer in our center.
Materials And Method: The clinical data of 93 patients with locally advanced cervical squamous cell cancer who received external beam radiotherapy (EBRT) combined with IGABT ± chemotherapy in our center were retrospectively analyzed. The disease stage, overall treatment time (OTT), chemotherapy, and the dose-volume parameters D, D, and D of GTV, the intermediate-risk clinical target volume (CTV), and the high-risk clinical target volume (CTV) of the patients were statistically analyzed. Kaplan-Meier and uni- and multivariable Cox regression analyses were used to analyze 2‑year overall survival (OS), progression-free survival (PFS), and local control rate (LC). A probit model was employed to assess the dose-effect relationship between the volume and dose-volume parameters of GTV and 2‑year OS, PFS, and LC.
Results: The median follow-up time was 19.6 months and 2‑year OS, PFS, and LC were 79.6%, 68.8%, and 94.6%, respectively. CTV D was an independent influencing factor for 2‑year PFS (P = 0.041); GTV volume was an independent factor for 2‑year OS, PFS, and LC (P < 0.001). The probit model showed that at GTV volume < 32.86 cm, the expected 2‑year LC was > 90%; at GTV D > 129.12 Gy, the expected 2‑year OS was > 90%.
Conclusion: Both the volume and dose-volume parameters of GTV are promising predictors in assessment of IGABT prognosis of cervical cancer.
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| http://dx.doi.org/10.1007/s00066-022-02000-6 | DOI Listing |
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