Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: To investigate the choriocapillaris changes associated with pachychoroid pigment epitheliopathy (PPE) in comparison with healthy eyes.
Methods: Nine 3 × 3 mm macular optical coherence tomography angiography images were acquired in patients with PPE and age-matched healthy participants. Multiple en face image averaging of the choriocapillaris was binarized for quantitative image analysis of the flow voids. In PPE eyes, we evaluated the presence of pachyvessels and the association between the location of the choriocapillaris flow deficit and pachyvessels.
Results: Thirty-two eyes with PPE and 30 eyes of healthy participants were included. In PPE eyes, the mean total area (1.16 ± 0.18 vs. 0.91 ± 0.16, p < 0.001) and average size of the flow voids (790 ± 144 vs. 520 ± 138; p < 0.001) were significantly larger than those in control eyes. Composite images of the choriocapillaris and choroid showed choriocapillaris flow deficits just above and outside the pachyvessels. The mean proportion of the flow void area overlying the pachyvessels against the whole flow void area of the choriocapillaris was 21.3% ± 10.2% (9.38%-44.42%) in PPE eyes.
Conclusions: In PPE eyes, the blood flow area of the choriocapillaris decreased diffusely within the macular area compared to control eyes, and the choriocapillaris flow deficit was not necessarily related to pachyvessel location.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467345 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271747 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Quantification of Normative Human Choriocapillaris Measures Across the Macula.
Invest Ophthalmol Vis Sci
September 2025
Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, United States.
Purpose: To assess macular choriocapillaris (CC) metrics in healthy volunteers (HVs) without ocular disease and demonstrate CC variations in patients with inherited retinal dystrophies (IRDs) using adaptive optics optical coherence tomography angiography (AO-OCTA).
Methods: Twenty-one HVs and three IRD patients were imaged. Macular variation in 20 HVs in CC metrics (CC density, CC diameter, CC tortuosity, void diameter, void area, lobule count, lobule area, and RPE-CC distance) were assessed by imaging a 28° strip of overlapping AO-OCTA volumes (3° × 3°) from the optic nerve head to the temporal macula.
Reduced model aided fluid-structure interaction design framework for shunt systems.
Med Eng Phys
October 2025
Department of Engineering Science, University of Oxford, United Kingdom. Electronic address:
Traditionally, clinical devices are designed, tested and improved through lengthy and expensive laboratory experiments and clinical trials [1]. More recently, computational methods have allowed for rapid testing, speeding up the design process and enabling far more complete searches of design space. While computational models cannot fully capture the complexities of biological systems, they provide valuable insights into crucial underlying mechanisms, such as the effects of fluid-structure interactions (FSIs).
View Article and Find Full Text PDFQuantifying Choriocapillaris Flow Deficits in Diabetic Retinopathy Using Projection-Resolved OCT Angiography.
Invest Ophthalmol Vis Sci
September 2025
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.
Purpose: To quantify choriocapillaris (CC) flow deficits using projection-resolved optical coherence tomographic angiography (PR-OCTA) and to evaluate whether they are correlated with diabetic retinopathy (DR).
Methods: In this retrospective study, OCTA scans covering a range of DR severities were acquired. Shadowing artifacts caused by hard exudates, large inner retinal vessels, and vitreous floaters were detected, along with the retinal fluid area.
Near-Real Surgical Specimens (NRSS): A Novel Platform for Standardized Assessment of Suprachoroidal Drug Delivery.
Transl Vis Sci Technol
September 2025
The Centers for Advanced Surgical Exploration (CASEx), Miami, FL, USA.
Purpose: Suprachoroidal (SC) drug delivery is a promising avenue for treating posterior segment ocular diseases. Current ex vivo models, primarily human cadaveric eyes, are limited by tissue variability and altered post-mortem fluid dynamics. We introduce near-real surgical specimens (NRSS), an engineered ocular tissue platform, to overcome these limitations and provide standardized, reproducible evaluation of SC drug delivery.
View Article and Find Full Text PDFShort-Term Effects of Dark Chocolate on Choroidal Parameters in Myopic Patients During Near Work.
Curr Eye Res
September 2025
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, P.R. China.
Purpose: To explore the effects of dark chocolate during relaxation and near work on choroidal thickness and blood flow parameters in myopic patients.
Methods: Thirty-one myopic subjects were recruited for this self-controlled study. Participants need to complete two experiments.