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Purpose: To explore the effects of dark chocolate during relaxation and near work on choroidal thickness and blood flow parameters in myopic patients.
Methods: Thirty-one myopic subjects were recruited for this self-controlled study. Participants need to complete two experiments. Experiment 1: Subjects first underwent a 10-minute washout process (0 diopter), followed by 20 min of near work (5 diopter). Experiment 2: After consuming 30 grams of dark chocolate 2 h in advance, subjects underwent the washout and near work procedures. Choroidal parameters were measured using swept-source optical coherence tomography angiography (SS-OCT/OCTA). Parameters comprised mean choroidal thickness (ChT), choriocapillaris perfusion area (CCPA), along with choroidal vessel volume (CVV) and three-dimensional choroidal vascularity index (CVI) quantified specifically for large- and middle-sized vessels.
Results: After consuming dark chocolate, ChT and CCPA significantly increased during relaxation in individuals with myopia. Both experiments found that the choroidal blood flow decreased significantly after near work, but the ChT decreased significantly only after consumption of dark chocolate. Furthermore, there were significant differences in the changes of CCPA and CVI between the two experiments.
Conclusions: After consumption of dark chocolate for two hours, a positive effect on choroidal thickness and blood flow was observed under relaxed condition. No evidence was found that consumption of dark chocolate could inhibit the reduction in choroidal thickness or blood flow during near work.
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http://dx.doi.org/10.1080/02713683.2025.2551167 | DOI Listing |
Curr Eye Res
September 2025
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, P.R. China.
Purpose: To explore the effects of dark chocolate during relaxation and near work on choroidal thickness and blood flow parameters in myopic patients.
Methods: Thirty-one myopic subjects were recruited for this self-controlled study. Participants need to complete two experiments.
Curr Res Food Sci
August 2025
Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
The use of polyols as sucrose-replacer in chocolate formulation has increased in the last years because of the high occurrence of the metabolic syndrome. Furthermore, chocolate is a qualified vehicle of functional ingredients such as probiotics that improve health in people with diabetes. The first objective of this study was to evaluate the optimal formulation of sucrose-free dark chocolate (SFDC) using a mixture design.
View Article and Find Full Text PDFJ Agric Food Chem
September 2025
Chair of Special Food Chemistry, Technische Universität Dresden, D-01062 Dresden, Germany.
During chocolate production, thermal processes such as roasting and conching promote nonenzymatic browning reactions such as the Maillard reaction and caramelization. In the present work, the MRPs furosine, 3-deoxyglucosone (3-DG), 3-deoxygalactosone (3-DGal), 5-hydroxymethylfurfural (HMF), -ε-fructosyllysine, -ε-lactulosyllysine, -ε-carboxymethyllysine (CML), -ε-carboxyethyllysine (CEL), pyrraline, methylglyoxal-derived hydroimidazolone 1 (MG-H1), formyline, maltosine, and rhamnolysine were quantitated in 4 filled, 12 dark, 11 milk, and 4 white chocolate samples. The predominant MRP in filled chocolates was -ε-fructosyllysine (up to 2662 mg/kg of chocolate), whereas in milk chocolates, it was -ε-lactulosyllysine (up to 883 mg/kg of chocolate).
View Article and Find Full Text PDFSports (Basel)
August 2025
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Open University, Via di Val Cannuta 247, 00166 Rome, Italy.
Background: The relationship between sports participation and food preferences in adults, as well as the influence of gender, is still unclear.
Objective: The objective of this study was to investigate the association between sports participation and individual food preferences and to explore potential gender differences among sports participants in a large group of Italian adults.
Methods: This cross-sectional study involved 2665 adults (aged ≥ 18 years) who lead normal lives and underwent a routine lifestyle and dietary assessment at a clinical centre specialising in nutrition, metabolic health, and lifestyle counselling in Rome.
Antioxidants (Basel)
July 2025
Unit of Molecular Biology and Nutrigenomics, School of Pharmacy and Health Products, University of Camerino, 62032 Camerino, Italy.
Chickpeas are used as alternative protein sources in healthy snacks due to their bioactive compounds beneficial for gut health. Combining chickpeas with dark chocolate improves palatability and may enhance biological functionality, although mechanistic evidence is still limited. In this explorative research, we evaluate the nutrigenomic, antioxidant and anti-inflammatory properties of a chickpea and chocolate snack using in vitro Caco-2 (colon adenocarcinoma cells) and THP-1 (monocyte-derived macrophages) models.
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