Synthetic CT in Musculoskeletal Disorders: A Systematic Review.

Invest Radiol

From the Department of Radiology, University of California San Diego, La Jolla, and the Research Service, Veterans Affairs San Diego Healthcare System, California.

Published: January 2023


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Repeated computed tomography (CT) examinations increase patients' ionizing radiation exposure and health costs, making an alternative method desirable. Cortical and trabecular bone, however, have short T2 relaxation times, causing low signal intensity on conventional magnetic resonance (MR) sequences. Different techniques are available to create a "CT-like" contrast of bone, such as ultrashort echo time, zero echo time, gradient-echo, and susceptibility-weighted image MR sequences, and artificial intelligence. This systematic review summarizes the essential technical background and developments of ultrashort echo time, zero echo time, gradient-echo, susceptibility-weighted image MR imaging sequences and artificial intelligence; presents studies on research and clinical applications of "CT-like" MR imaging; and describes their main advantages and limitations. We also discuss future opportunities in research, which patients would benefit the most, the most appropriate situations for using the technique, and the potential to replace CT in the clinical workflow.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742139PMC
http://dx.doi.org/10.1097/RLI.0000000000000916DOI Listing

Publication Analysis

Top Keywords

echo time
16
systematic review
8
ultrashort echo
8
time echo
8
time gradient-echo
8
gradient-echo susceptibility-weighted
8
susceptibility-weighted image
8
sequences artificial
8
artificial intelligence
8
synthetic musculoskeletal
4

Similar Publications

Study Objectives: Research linking children's sleep to cognitive outcomes is inconsistent and has largely focused on one aspect of sleep, such as duration, rather than measuring multiple dimensions of sleep health. We hypothesized that children's sleep health would be positively associated with inhibitory control and cognitive functioning.

Method: We cross-sectionally assessed 1595 participants (ages 7-11) from the Environmental influences on Child Health Outcomes cohort using the NIH Toolbox Cognition Battery, Environmental influences on Child Health Outcomes Sleep Health of Children and Adolescents questionnaire, and Patient Reported Outcome Measurement Information System Sleep Disturbance/Sleep-related Impairment instruments.

View Article and Find Full Text PDF

Introduction: Repaired total anomalous pulmonary venous connection (TAPVC) patients with preoperative pulmonary venous obstruction (PVO) have reductions in echocardiographic metrics, such as left atrial reservoir function and pulmonary venous variability index (PVVI). We hypothesized reduced preoperative left atrial strain mechanics in isolated TAPVC patients serve as risk factors for postoperative PVO. We also evaluated echocardiographic metrics and clinical characteristics associated with preoperative and postoperative PVO, as well as compared these to healthy controls.

View Article and Find Full Text PDF

Short water transit times determine the fate of veterinary pharmaceuticals in lowland catchments.

J Contam Hydrol

August 2025

Faculty of Geoscience and the Environment, University of Lausanne, Lausanne, Switzerland; Laboratory of Ecohydrology ENAC/IIE/ECHO, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Livestock animals are commonly treated with veterinary pharmaceuticals (VPs), and their residues often enter the environment through manure applied to soil. A fraction of these residues may be further transported to surface waters through intricate transport mechanisms. Here, we examine the temporal dynamics of VPs in lowland surface waters of an agricultural catchment in the Netherlands, utilizing information on VPs concentrations in manure (2015-2020) and surface water measurements collected in 2020.

View Article and Find Full Text PDF

Artificial Intelligence Automation of Echocardiographic Measurements.

J Am Coll Cardiol

August 2025

Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Department of Cardiology, Kaiser Permanente Santa Clara Medical Center, Santa Clara, California, USA. Electronic address:

Background: Accurate measurement of echocardiographic parameters is crucial for the diagnosis of cardiovascular disease and tracking of change over time; however, manual assessment requires time-consuming effort and can be imprecise. Artificial intelligence has the potential to reduce clinician burden by automating the time-intensive task of comprehensive measurement of echocardiographic parameters.

Objectives: The purpose of this study was to develop and validate open-sourced deep learning semantic segmentation models for the automated measurement of 18 anatomic and Doppler measurements in echocardiography.

View Article and Find Full Text PDF

Since its introduction more than 30 years ago, the blood oxygenation level-dependent (BOLD) contrast remains the most widely used method for functional MRI (fMRI) in humans and animal models. The BOLD contrast is typically acquired with echo planar imaging (EPI) to obtain sensitization of the signal during the echo time (TE) to dynamic changes in deoxyhemoglobin content, while achieving high spatiotemporal resolution and full brain coverage. However, EPI-based fMRI also faces multiple shortcomings, including sensitivity to body motion, susceptibility-related signal dropouts, interference with multimodal sensors, and loud acoustic noise.

View Article and Find Full Text PDF