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To determine the minimum number of endotracheal intubation (ETI) attempts necessary for a novice emergency medicine (EM) trainee to become proficient with this procedure. This single-center study retrospectively analyzed data obtained from the institutional airway registry during the period from April 2014 to March 2021. All ETI attempts made by EM trainees starting their residency programs between 2014 and 2018 were evaluated. We used a first attempt success (FAS) rate of 85% as a proxy for ETI proficiency. Generalized linear mixed models were used to evaluate the association between FAS and cumulative ETI experience. The number of ETI attempts required to achieve an FAS rate of ≥ 85% was estimated using the regression coefficients obtained from the model. The study period yielded 2077 ETI cases from a total of 1979 patients. The FAS rate was 78.6% (n = 1632/2077). After adjusting for confounding factors, the cumulative number of ETI cases was associated with increased FAS (adjusted odds ratio, 1.010 per additional ETI case; 95% confidence interval 1.006-1.013; p < 0.001). A minimum of 119 ETI cases were required to establish a ≥ 85% likelihood of FAS. At least 119 ETI cases were required for EM trainees to achieve an FAS rate of ≥ 85% in the emergency department.
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http://dx.doi.org/10.1038/s41598-022-19337-8 | DOI Listing |
Surg Endosc
September 2025
Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road No.154, Tianjin, 300052, China.
Introduction: Colorectal cancer (CRC) ranks as the second deadliest cancer globally, impacting patients' quality of life. Colonoscopy is the primary screening method for detecting adenomas and polyps, crucial for reducing long-term CRC risk, but it misses about 30% of cases. Efforts to improve detection rates include using AI to enhance colonoscopy.
View Article and Find Full Text PDFJ Cell Mol Med
September 2025
Department of Orthopedic Surgery, Show-Chwan Memorial Hospital, Changhua, Taiwan, ROC.
Osteosarcoma (OS) is an aggressive malignancy characterised by high metastatic potential and poor prognosis. Imipramine, a tricyclic antidepressant, has shown potential anticancer effects. This study evaluates the cytotoxic, pro-apoptotic and anti-invasion effects of imipramine on OS cells in vitro and in vivo, as well as its underlying mechanisms.
View Article and Find Full Text PDFJ Cosmet Dermatol
September 2025
Research Center of Artificial Intelligence in Health, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: The facial artery (FA), as the primary vascular structure of the face, exhibits numerous anatomical variations. Determining its anatomical variation (vascular mapping) by ultrasonography (US)-a non-invasive, low-cost, practical, and bedside-applicable imaging technique-helps achieve safe aesthetic injections, averting complications such as ischemia and necrosis.
Objectives: This study aimed to evaluate the anatomical characteristics of FA under the guidance of US, including course variations in relation to the nasolabial fold (NLF), depth, and diameter.
Cancers (Basel)
August 2025
Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev Ave., 8, Novosibirsk 630090, Russia.
: Neutrophils have recently gained significant attention due to their heterogeneity in tumor settings. Recent data showed neutrophil pro- and anti-tumor profiles during tumor progression. However, the concessive causes of neutrophil skewing toward one or another profile are not fully understood.
View Article and Find Full Text PDFRSC Adv
August 2025
Faculty of Biology and Environment, Ho Chi Minh City University of Industry and Trade (HUIT) 140 Le Trong Tan Street, Tay Thanh Ward Ho Chi Minh City Vietnam.
Landfill leachate is a major environmental concern because of its high content of persistent organic compounds (POCs), which require advanced treatment techniques. This study introduces a novel hybrid ozonation-TiO-modified fly ash composite (FA@TiO) process enhanced by a peroxymonosulfate (PMS) for POC degradation in landfill leachate. The FA@TiO composite, synthesized the sol-gel method with optimal 20% TiO loading, leverages fly ash's cost-effectiveness and TiO's catalytic prowess.
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