Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: Selective serotonin reuptake inhibitors (SSRIs) are the preferred treatments for depression. The most common adverse drug reactions are symptoms involving the digestive system, leading to low compliance in patients with depression. Therefore, it is important to assess the safety of SSRIs with respect to the digestive system. Several meta-analyses have compared the risks of digestive side effects of SSRIs and other antidepressants. We aimed to compare the risks of various SSRIs (fluoxetine, escitalopram, citalopram, paroxetine, and sertraline) for adverse reactions of the digestive system.
Methods: Systematic searches returned 30 randomized controlled trials (n = 5004) of five antidepressants and placebos.
Results: Fluoxetine had the lowest probability of digestive side effects, ranking fifth at 0.548. Sertraline had the highest probability of digestive side effects, with a probability of 0.611. For gastrointestinal tolerability, escitalopram was better than paroxetine (odds ratio [OR] =0.62, 95% confidence interval [CI] 0.43-0.87) and sertraline (OR=0.56, 95% CI 0.32-0.99).
Conclusion: Fluoxetine exhibited distinct advantages compared to other SSRIs, while sertraline had the greatest likelihood of digestive system side effects. These findings will help doctors understand the relative advantages of various antidepressants.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386738 | PMC |
| http://dx.doi.org/10.2147/TCRM.S363404 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
PREVALENCE OF HELICOBACTER PYLORI INFECTION AMONG GASTROENTEROLOGISTS AND GASTROENDOSCOPISTS IN BRAZIL.
Arq Gastroenterol
September 2025
Hospital das Clínicas da Universidade Federal de Minas Gerais/Ebserh, Instituto Alfa de Gastroenterologia; Belo Horizonte, MG, Brasil.
Background: Most Helicobacter pylori (H. pylori) infections are acquired in childhood. It remains uncertain whether gastroenterologists involved in endoscopic procedures face an increased occupational risk of H.
View Article and Find Full Text PDFTHE HIGH RESOLUTION ESOPHAGEAL MANOMETRY AND PREDICTORS PARAMETERS OF DYSPHAGIA IN POST-LAPAROSCOPIC HIATOPLASTY AND NISSEN FUNDOPLICATION - A SYSTEMATIC REVIEW.
Arq Gastroenterol
September 2025
State University of Campinas, Faculty of Medical Sciences, Department of Surgery, Digestive Diseases Surgical Unit - Campinas (SP), Brazil.
Background: Gastroesophageal reflux disease has a prevalence of 12% in the Brazilian population. Its treatment includes hygienic-dietary changes, use of medications and, in selected cases, surgery with laparos-copic hiatoplasty and Nissen total fundoplication. However, this last treatment modality presents risks of postoperative dysphagia.
View Article and Find Full Text PDFConcomitant use of anti-leishmanial therapy and antibacterial prophylaxis reduces plasma LPS levels and improves several aspects of experimental Leishmania infantum infection in golden hamsters.
Mem Inst Oswaldo Cruz
September 2025
Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório Interdisciplinar de Pesquisas Médicas, Rio de Janeiro, RJ, Brasil.
Background: Parasite antigens and plasma lipopolysaccharide (LPS) levels from luminal origin in visceral leishmaniasis (VL) patients are correlated with cellular activation and low CD4+T cell counts.
Objectives: Our aim was to verify whether Leishmania infantum infection damages the intestinal barrier and whether combination antimonial/antibiotic contributes to the reduction of LPS levels and immune activation.
Methods: Golden hamsters were grouped in: G1-uninfected; G2-infected with L.
Effect of dentition status on perceived mobility limitation among older Brazilian adults: a cohort study.
Braz Oral Res
September 2025
Universidade de São Paulo - USP, School of Medicine of Ribeirão Preto, Ribeirão Preto, SP, Brazil.
This study aimed to evaluate the longitudinal effect of dentition status on the perceived mobility limitation of community-dwelling Brazilian older adults. This cohort study used data from individuals who participated in the second (2006), third (2010), and fourth (2015) waves of the Health Well-being and Aging Study, conducted in the urban region of the city of São Paulo, Brazil, with adults aged 60 years and older. Mobility limitation was assessed in all waves according to reports of difficulty in performing seven activities, with higher scores representing a higher number of limitations.
View Article and Find Full Text PDFSingle-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs of type 1 diabetes progression.
Sci Adv
September 2025
Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Cell type-specific regulatory programs that drive type 1 diabetes (T1D) in the pancreas are poorly understood. Here, we performed single-nucleus multiomics and spatial transcriptomics in up to 32 nondiabetic (ND), autoantibody-positive (AAB), and T1D pancreas donors. Genomic profiles from 853,005 cells mapped to 12 pancreatic cell types, including multiple exocrine subtypes.
View Article and Find Full Text PDF