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http://dx.doi.org/10.1111/trf.17064 | DOI Listing |
Ann Med
December 2025
Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Background: Thrombocytopenia (TCP) and coagulation disorders are common complications for patients with liver cirrhosis. The impact of severe TCP [30 × 10/L < platelets (PLT) ≤ 50 × 10/L] and coagulation disorder on bleeding risk after Hassab's operation or partial hepatectomy (PH) for cirrhotic patients is unclear.
Method: Our study retrospectively enrolled 724 cirrhotic patients from July 2019 to August 2024, including 189 patients who underwent Hassab's operation and 535 patients with hepatocellular carcinoma who underwent PH without prophylactic platelet transfusions or thrombopoietin receptor agonists.
BMJ Open
September 2025
Jiangsu Provincial Key Laboratory of Critical Care Medicine, Nanjing, Jiangsu, China
Objectives: To systematically compare the effects of various antithrombotic strategies on prespecified outcomes including 28-day all-cause mortality (primary outcome), major thrombotic events and major bleeding events (secondary outcomes) in adult COVID-19 patients.
Design: Systematic review and Bayesian network meta-analysis (NMA).
Data Sources: PubMed, Web of Science, Embase, Cochrane Library and ClinicalTrials.
CEN Case Rep
September 2025
Department of Pediatric Nephrology, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, 162-8666, Japan.
MYH9-related disease is an autosomal dominant genetic disease characterized by congenital macrothrombocytopenia, sensorineural hearing loss, and progressive kidney failure. Severe cases require kidney replacement therapy in the patient's second decade of life, and thrombocytopenia constitutes a major risk factor for hemorrhagic complications during dialysis initiation or kidney transplantation. Serious bleeding complications have been reported to occur in the perioperative period despite adequate platelet transfusions.
View Article and Find Full Text PDFArq Bras Cir Dig
August 2025
Rede D'Or, Hospital São Carlos Hospital - Fortaleza (CE), Brazil.
Background: Orthotopic liver transplantation (OLT) is a highly complex procedure.
Background: OLT can be difficult to control intraoperative bleeding in patients with coagulopathies.
Background: OLT may result in a high need for transfusion of blood products.
Transfusion
August 2025
Servicio de Hematología y Hemoterapia, Hospital Universitario Miguel Servet, Zaragoza, Spain.
Background: Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare autosomal recessive thrombotic microangiopathy caused by biallelic mutations in ADAMTS13, leading to severe enzyme deficiency. The absence of ADAMTS13 prevents cleavage of ultra-large von Willebrand factor multimers, resulting in platelet-rich microthrombi formation. Pregnancy is a known precipitation factor, and early diagnosis and plasma treatment regimen to increase the ADAMTS13 activity is essential to prevent maternal and fetal complications.
View Article and Find Full Text PDF