Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Vitreoretinal mechanics plays an important role in retinal trauma and many sight-threatening diseases. In age-related pathologies, such as posterior vitreous detachment and vitreomacular traction, lingering vitreoretinal adhesions can lead to macular holes, epiretinal membranes, retinal tears and detachment. In age-related macular degeneration, vitreoretinal traction has been implicated in the acceleration of the disease due to the stimulation of vascular growth factors. Despite this strong mechanobiological influence on trauma and disease in the eye, fundamental understanding of the mechanics at the vitreoretinal interface is limited. Clarification of adhesion mechanisms and the role of vitreoretinal mechanics in healthy eyes and disease is necessary to develop innovative treatments for these pathologies. In this review, we evaluate the existing literature on the structure and function of the vitreoretinal interface to gain insight into age- and region-dependent mechanisms of vitreoretinal adhesion. We explore the role of vitreoretinal adhesion in ocular pathologies to identify knowledge gaps and future research areas. Finally, we recommend future mechanics-based studies to address the critical needs in the field, increase fundamental understanding of vitreoretinal mechanisms and disease, and inform disease treatments.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9552593 | PMC |
| http://dx.doi.org/10.1016/j.jmbbm.2022.105399 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluating Posterior Vitreous Detachment Annotation Consistency on OCT Scans in Patients with Disease of the Vitreomacular Interface.
Retina
September 2025
Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 15, CH-3010.
Purpose: To evaluate inter-grader variability in posterior vitreous detachment (PVD) classification in patients with epiretinal membrane (ERM) and macular hole (MH) on spectral-domain optical coherence tomography (SD-OCT) and identify challenges in defining a reliable ground truth for artificial intelligence (AI)-based tools.
Methods: A total of 437 horizontal SD-OCT B-scans were retrospectively selected and independently annotated by six experienced ophthalmologists adopting four categories: 'full PVD', 'partial PVD', 'no PVD', and 'ungradable'. Inter-grader agreement was assessed using pairwise Cohen's kappa scores.
Resolution of Vitreomacular Traction Following a Commercial Flight Simulator Experience.
J Vitreoretin Dis
August 2025
Truhlsen Eye Institute, Department of Ophthalmology, University of Nebraska Medical Center, Omaha, NE, USA.
To describe the effect of rotational forces on the vitreoretinal interface in a case of vitreomacular traction. Retrospective, observational case report. A 66-year-old woman presented with symptomatic vitreomacular traction with reduced visual acuity to 20/60.
View Article and Find Full Text PDFIn vivo detection of macrophage-like cells at the vitreoretinal interface in retinal diseases using optical coherence tomography angiography.
Surv Ophthalmol
August 2025
Department of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400012, China. Electronic address:
Retinal diseases represent a group of vision-threatening disorders with a complex pathogenesis that involves interactions among various cellular and molecular factors. Inflammation and immune cells play a pivotal role in the initiation, progression, and repair of retinal diseases. Recently, advancements in optical coherence tomography angiography (OCTA) technology have enabled the in vivo detection of macrophage-like cells (MLCs) at the vitreoretinal interface and allowed for assessment of retinal inflammation, representing a landmark advancement for understanding the pathophysiology of retinal diseases, particularly regarding the role of MLCs.
View Article and Find Full Text PDFWaveAttention-ResNet: a deep learning-based intelligent diagnostic model for the auxiliary diagnosis of multiple retinal diseases.
Front Radiol
July 2025
Shanxi Eye Hospital, Taiyuan, Shanxi, China.
Objective: This study constructs a deep learning-based combined algorithm named WaveAttention ResNet (WARN) to investigate the classification accuracy for seven common retinal diseases and the feasibility of AI-assisted diagnosis in this field.
Methods: First, a deep learning-based classification network is constructed. The network is built upon ResNet18, integrated with the Convolutional Block Attention Module (CBAM) and wavelet convolution modules, forming the WARN method for retinal disease classification.
When less is more: the role of non-vitrectomized vitreous surgery in retinal diseases.
Int J Retina Vitreous
August 2025
Department of Ophthalmology, Bernice and Harvey Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, 72223, Arkansas, USA.
Unlabelled: Anatomically, the vitreous is not merely a transparent medium; it is a complex gel structure crucial for maintaining intraocular architecture and biochemical homeostasis. By minimizing disturbance to the vitreous, non-vitrectomized vitreous Surgery (NVS) which involves surgery with no or minimal removal of the vitreous gel, attempts to achieve the indication of the surgery while preserving the vitreous’ physiological functions, such as buffering intraocular oxygen tension and limiting the influx of inflammatory cells. This selective approach is especially relevant in younger patients with clear crystalline lenses, and in those with healthy peripheral retinas.
View Article and Find Full Text PDF