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The need to develop new treatments to prevent unprompted premature delivery before 37 weeks of pregnancy remains pressing and unmet. Bacteria ( species) that promote vaginal health produce biochemical compounds that prevent the growth of microbes such as . Overgrowth of can cause vaginal infection with smelly discharge and increase a woman's risk of sexually transmitted infections and premature delivery. In this study, we examined how normal health-promoting () and potentially harmful () vaginal bacteria interact in a laboratory setting. This was in order to observe natural and effective agent(s) from that can hinder the growth of and accompanying immune response. We observed that clears by itself and with several biochemical compounds that it produces. Such biochemical compounds can be developed into treatment for vaginal infections and premature delivery due to infection and inappropriate immune response.
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http://dx.doi.org/10.1530/RAF-22-0026 | DOI Listing |
Adv Healthc Mater
September 2025
Smart Polymeric Biomaterials Research Group, Campus Group T, KU Leuven, Andreas Vesaliusstraat 13, Leuven, 3000, Belgium.
The lower gastrointestinal (GI) tract is affected by a range of diseases, including colorectal cancer and inflammatory bowel disease, among others. Effective treatment of these conditions requires drug delivery systems (DDSs) capable of precise targeting. While pH- and enzyme-sensitive DDSs are the most used, they often suffer from premature drug release and target specificity, limiting their efficacy.
View Article and Find Full Text PDFJ Obstet Gynaecol Res
September 2025
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Aims: Preterm delivery (PTD) is a leading cause of neonatal morbidity and mortality. Accurate prediction is crucial for optimizing clinical outcomes, particularly in women with a short cervix. Although fetal fibronectin (FFN) is widely used to predict PTD, placental alpha-microglobulin-1 (PAMG-1) has gained attention for its potential to improve predictive accuracy.
View Article and Find Full Text PDFBMC Infect Dis
September 2025
Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, No.20, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, P.R. China.
Background: Early-onset neonatal sepsis (EOS) is a critical condition primarily caused by maternal-fetal transmission of bacterial pathogens during delivery, with Escherichia coli and Group B Streptococcus being the most prevalent. However, neonatal sepsis can also involve other rare bacteria, including Corynebacterium amycolatum, which was first described in 1988 and is widely recognized as an emerging pathogen in infectious diseases.
Case Presentation: A male infant was admitted to the neonatal intensive care unit (NICU) due to premature birth and tachypnea.
J Reprod Immunol
September 2025
University of Toyama, 3190 Gofuku, Toyama-shi, Toyama 930-8555, Japan. Electronic address:
A highly sensitive PCR method developed in our university accurately identifies the presence or absence of intra-uterine (IU) microbes without false positive results. With the inclusion of the results of an accurate assessment of IU microbes, risk factors for the development of moderate/severe bronchopulmonary dysplasia (BPD), a chronic lung disease that affects premature infants who require prolonged oxygen therapy or medical ventilation, were examined in 107 spontaneous preterm neonates. Perinatal risk factors were compared between cases of moderate/severe BPD (N = 49) and mild/non-BPD (N = 58).
View Article and Find Full Text PDFPediatr Neurol
August 2025
Department of Neonatology, Centro Hospitalar e Universitário de São João, Porto, Portugal. Electronic address:
Background: Recent studies demonstrated associations between hematological parameters and indices (HPI) obtained from full blood count (FBC) collected on the first day of life (D1) and the occurrence of intraventricular hemorrhage (IVH) in premature infants. Our objective was to evaluate the association between HPI obtained from the FBC of D1 and the occurrence of IVH in premature infants, to assess whether these can be used as prognostic markers.
Methods: This is a retrospective study, including preterm infants with gestational age below 30 weeks.