Risk factors for moderate/severe bronchopulmonary dysplasia: A retrospective cohort study including results of an accurate assessment of intra-uterine microbes.

A highly sensitive PCR method developed in our university accurately identifies the presence or absence of intra-uterine (IU) microbes without false positive results. With the inclusion of the results of an accurate assessment of IU microbes, risk factors for the development of moderate/severe bronchopulmonary dysplasia (BPD), a chronic lung disease that affects premature infants who require prolonged oxygen therapy or medical ventilation, were examined in 107 spontaneous preterm neonates. Perinatal risk factors were compared between cases of moderate/severe BPD (N = 49) and mild/non-BPD (N = 58).

Exposure-dependent incorporation of trifluridine into DNA of tumors and white blood cells in tumor-bearing mouse.

Purpose: Trifluridine (TFT) is an antitumor component of a novel nucleoside antitumor agent, TAS-102, which consists of TFT and tipiracil hydrochloride (thymidine phosphorylase inhibitor). Incorporation of TFT into DNA is a probable mechanism of antitumor activity and hematological toxicity. The objective of this study was to examine the TFT incorporation into tumor- and white blood cell-DNA, and to elucidate the mechanism of TFT-related effect and toxicity.

Duodenal lymphangitis carcinomatosa: endoscopic characteristics and clinical significance.

Background And Aim: Duodenal lymphangitis carcinomatosa has been sporadically described, but so far little attention has been paid to duodenal lymphangitis carcinomatosa.

Methods: Four cases with duodenal lymphangitis carcinomatosa were endoscopically and histologically examined.

Results: The four cases exhibited multiple polypoid lesions along the Kerckring's folds and/or were covered by characteristically granular, non-ulcerated mucosa upon thickening.