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Background: Most antibiotics are prescribed in the ambulatory setting with estimates that up to 50% of use is inappropriate. Understanding factors associated with antibiotic misuse is essential to advancing better stewardship in this setting. We sought to assess the frequency of unnecessary antibiotic use for upper respiratory infections (URIs) among primary care providers and identify patient and provider characteristics associated with misuse.
Methods: Unnecessary antibiotic prescribing was assessed in a descriptive study by using adults ≥18 years seen for common URIs in a large, Upper Midwest, integrated health system, electronic medical records from June 2017 through May 2018. Individual provider rates of unnecessary prescribing were compared for primary care providers practicing in the departments of internal medicine, family medicine, or urgent care. Patient and provider characteristics associated with unnecessary prescribing were identified with a logistic regression model.
Results: A total of 49 463 patient encounters were included. Overall, antibiotics were prescribed unnecessarily for 42.2% (95% confidence interval [CI], 41.7-42.6) of the encounters. Patients with acute bronchitis received unnecessary antibiotics most frequently (74.2%; 95% CI, 73.4-75.0). Males and older patients were more likely to have an unnecessary antibiotic prescription. Provider characteristics associated with higher rates of unnecessary prescribing included being in a rural practice, having more years in practice, and being in higher volume practices such as an urgent care setting. Fifteen percent of providers accounted for half of all unnecessary antibiotic prescriptions.
Conclusions: Although higher-volume practices, a rural setting, or longer time in practice were predictors, unnecessary prescribing was common among all providers.
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http://dx.doi.org/10.1093/ofid/ofac302 | DOI Listing |
Klin Mikrobiol Infekc Lek
June 2025
Clinic of Infectious Diseases, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic, e-mail:
Acute bacterial skin and soft tissue infections represent a common clinical problem, and accurate diagnosis is crucial for initiating appropriate therapy. However, conditions such as cellulitis and erysipelas can be clinically mimicked by a variety of non-infectious conditions, including eczematous, venous, lymphatic, and autoimmune diseases. This review summarizes the key differences in clinical presentation, patient history, and laboratory findings that help distinguish true infections from their non-infectious mimickers.
View Article and Find Full Text PDFJ Pediatric Infect Dis Soc
September 2025
Department of General Pediatrics, Pediatric Infectious Disease and Internal Medicine, Robert Debré University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
In a 6-year observational study of 45 children with suspected septic arthritis and no pathogen identified, early antibiotic discontinuation based on strict clinical and biological criteria was not associated with relapse during the six-month period following hospitalization, supporting this approach may be safe and reduce unnecessary antibiotic exposure.
View Article and Find Full Text PDFFront Pediatr
August 2025
Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Aims: To characterize enteritis presenting as pseudo-appendicitis and identify distinguishing predicting factors.
Methods: This retrospective multicentre study included all children <18 years with confirmed infection, hospitalized from 2014 to 2023 for presumed appendicitis (pseudo-appendicitis group). Each case was matched with 2 controls with confirmed appendicitis.
World J Gastroenterol
August 2025
Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta 31511, Algharbia, Egypt.
Background: Epiploic appendagitis is a rare, often underrecognized cause of acute abdominal pain. Misdiagnosis can lead to unnecessary hospitalization, antibiotic use, or surgical intervention. Advances in imaging have improved the recognition of this self-limiting condition, but clinical awareness remains critical.
View Article and Find Full Text PDFJ Clin Microbiol
September 2025
Institute of Medical Microbiology, University of Zurich, Zürich, Switzerland.
is an opportunistic human pathogen with high genomic diversity. In the past, multi-drug resistance has been considered a hallmark of . However, some strains of are fully susceptible and thus, their reclassification would avoid the empirical therapy with glycopeptides.
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