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http://dx.doi.org/10.1002/ctm2.975 | DOI Listing |
Epigenomics
September 2025
College of Physical Education, Yangzhou University, Yangzhou, China.
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder lacking objective biomarkers for early diagnosis. DNA methylation is a promising epigenetic marker, and machine learning offers a data-driven classification approach. However, few studies have examined whole-blood, genome-wide DNA methylation profiles for ASD diagnosis in school-aged children.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
September 2025
The University of Leicester Ulverscroft Eye Unit, School of Psychology and Vision Sciences, University of Leicester, Leicester, United Kingdom.
Purpose: To define the genetic architecture of foveal morphology and explore its relevance to foveal hypoplasia (FH), a hallmark of developmental macular disorders.
Methods: We applied deep-learning algorithms to quantify foveal pit depth from central optical coherence tomography (OCT) B-scans in 61,269 UK Biobank participants. A genome-wide association study (GWAS) was conducted using REGENIE, adjusting for age, sex, height, and ancestry.
Zool Res
September 2025
College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China. E-mail:
The big-headed turtle ( ), currently the only extant member of the genus and the family Platysternidae, has undergone severe population declines driven by poaching, illegal trade, and habitat loss, leading to its classification as Critically Endangered (CR) by the International Union for Conservation of Nature (IUCN). Despite its conservation status, persistent taxonomic ambiguities and unresolved phylogenetic relationships have hindered effective protection and management. This study integrated evidence from genome-wide single nucleotide polymorphisms (SNPs), mitochondrial DNA sequences ( , ), and morphological data to reconstruct the phylogeny and phylogeography of and revise its taxonomy.
View Article and Find Full Text PDFPlant Genome
September 2025
Agriculture Victoria, Centre for AgriBioscience, AgriBio, Bundoora, Victoria, Australia.
Global wheat (Triticum aestivum L.) production faces significant challenges due to the destructive nature of leaf (Puccinia triticina; leaf rust [Lr]), stem (Puccinia graminis; stem rust [Sr]), and stripe (Puccinia striiformis; stripe rust [Yr]) rust diseases. Despite ongoing efforts to develop resistant varieties, these diseases remain a persistent challenge due to their highly evolving nature.
View Article and Find Full Text PDFBrain Behav
September 2025
Department of Thoracic Surgery II, Department of Lung Transplantation, Organ Transplantation Center, the First Hospital of Jilin University, Changchun, China.
Background: Ischemic stroke (IS) treatment remains a significant challenge. This study aimed to identify potential druggable genes for IS using a systematic druggable genome-wide Mendelian Randomization (MR) analysis.
Methods: Two-sample MR analysis was conducted to identify the causal association between potential druggable genes and IS.