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Non-standard structured, multivariate data are emerging in many research areas, including genetics and genomics, ecology, and social science. Suitably defined pairwise distance measures are commonly used in distance-based analysis to study the association between the variables. In this work, we consider a linear quantile regression model for pairwise distances. We investigate the large sample properties of an estimator of the unknown coefficients and propose statistical inference procedures correspondingly. Extensive simulations provide evidence of satisfactory finite sample properties of the proposed method. Finally, we applied the method to a microbiome association study to illustrate its utility.
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http://dx.doi.org/10.1007/s12561-021-09306-6 | DOI Listing |
Sci Rep
August 2025
Department of Computer Science, University of Taipei, Taipei, 100, Taiwan.
Mass spectrometry‑based proteomics using isobaric labeling technology has become popular for proteomic quantitation. Existing approaches rely on the mechanism of target-decoy search and false discovery rate control to examine whether a peptide-spectrum match (PSM) is utilized for quantitation. However, some PSMs passing the examination may still exhibit high quantitation errors, which can deteriorate the overall quantitation accuracy.
View Article and Find Full Text PDFSensors (Basel)
August 2025
Ferdinand-Braun-Institut (FBH), Gustav-Kirchhoff-Straße 4, 12489 Berlin, Germany.
Bragg gratings are fundamental components in a wide range of sensing applications due to their high sensitivity and tunability. In this work, we present an augmented Bayesian approach for efficiently acquiring limited but highly informative training data for machine learning models in the design and simulation of Bragg grating sensors. Our method integrates a distance-based diversity criterion with Bayesian optimization to identify and prioritize the most informative design points.
View Article and Find Full Text PDFMicroorganisms
August 2025
Faculty of Health Sciences, Juárez University of the State of Durango, Gómez Palacio 35050, Mexico.
Diet and gut microbiota are significant determinants of host health, but how dietary quality modulates gut microbiota in -colonised individuals remains underexplored. We studied two contrasting cohorts: university students (FACSA, n = 46) and institutionalised children with their caregivers (PAVILA, n = 37), representing distinct dietary and sociodemographic contexts. Eight participants from each cohort tested positive for ; however, two PAVILA samples could not be sequenced, resulting in a final microbiota subcohort of 14 individuals (FACSA n = 8, PAVILA n = 6).
View Article and Find Full Text PDFRapid Commun Mass Spectrom
December 2025
School of Chemical Science and Engineering, Tongji University, Shanghai, China.
Rationale: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a highly efficient technique for microbial identification; however, the accuracy has always been a problem when identifying closely related microbial species. Improving spectral data identification algorithms is one of the key approaches to enhancing the discriminatory power and reliability of identification for the closely related species.
Methods: This study develops a dimensionality reduction method based on inter-spectral distance computation for the analysis of MALDI-TOF MS data.
Neuroscience
August 2025
Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. Electronic address:
The growing need for reliable biometric systems to identify children in contexts such as vaccination tracking, missing child recovery, and hospital safety has highlighted the importance of using robust physiological markers. EEG signals have emerged as promising biometric indicators due to their resistance to external manipulation and forgery. In this study, we investigated the influence of emotional facial expressions on EEG-based biometric identification in children with and without Attention-Deficit/Hyperactivity Disorder (ADHD).
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