Variation and Renal Function in Chinese Patients With Hypertension.

Objective: (solute carrier family 12 member 3) gene variants are associated with diabetic nephropathy; however, their association with hypertensive nephropathy remains unknown. We aimed to investigate the association between gene polymorphisms and renal function in patients with hypertension.

Methods: Participants from three non-diabetic hypertensive cohorts, including young-onset hypertension (cohort 1, = 882), treatment-naïve hypertension (cohort 2, = 90), and follow-up cohort (cohort 3, = 166), underwent genotyping for single nucleotide polymorphisms in . Renal events were defined as a >25 and >50% decline in estimated glomerular filtration rate (eGFR).

Results: In cohort 1, rs16963397 C/C or C/G ( = 0.005), rs13334864 C/C or C/T ( = 0.020), and rs7187932 A/A or A/G polymorphisms ( = 0.014) had higher eGFRs compared to their counterparts, with similar findings observed in cohort 2. In cohort 3, over a mean follow-up of 5.8 ± 1.7 years, participants with either rs16963397 C/C or rs13334864 C/C polymorphisms had more >25 and >50% eGFR decline than their counterparts (log-rank test, = 0.058 and = 0.038, respectively). Cox regression analysis revealed that rs16963397 C/C and rs13334864 C/C polymorphisms were significantly associated with an increased risk of >25% [hazard ratio (HR), 3.294; 95% confidence interval (CI), 1.158-9.368; = 0.025] and >50% decline in eGFR (HR, 18.630; 95% CI, 1.529-227.005, = 0.022) than their counterparts.

Conclusion: polymorphisms are associated with renal function in Chinese patients with hypertension.