Anti-NMDA receptor encephalitis presenting as fever with undetermined cause.

Int J Infect Dis

Department of Internal Medicine and Infection Control Office, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwa

Published: September 2022


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Autoimmune encephalitis is a rare disease, which should be differentiated from aseptic encephalitis. Possessing anti-N-methyl-D-aspartate (NMDA) receptor autoantibody is the leading cause of autoimmune encephalitis. However, it may pose a diagnostic challenge to clinicians, especially to nonpsychiatric or non-neurologic specialist, resulting in a delayed initiation of treatment. Hence, we share the case of a patient with anti-NMDA receptor encephalitis who was hospitalized in the infectious diseases ward, presenting with acute febrile illness that preceded characteristic neuropsychiatric symptoms.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2022.06.019DOI Listing

Publication Analysis

Top Keywords

anti-nmda receptor
8
receptor encephalitis
8
autoimmune encephalitis
8
encephalitis
5
encephalitis presenting
4
presenting fever
4
fever undetermined
4
undetermined autoimmune
4
encephalitis rare
4
rare disease
4

Similar Publications

Anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis is an immune-mediated disease manifesting with a complex neuropsychiatric syndrome and anti-NMDA receptor antibodies within the cerebrospinal fluid. If not treated, it can progress to hypoventilation, coma, or death. It is often misdiagnosed as drug abuse, neuroleptic malignant syndrome, primary psychiatric disorder, or viral encephalitis.

View Article and Find Full Text PDF

Aims: Anti-N-methyl-d-aspartate (Anti-NMDA) receptor encephalitis is characterized by widespread neural dysfunction, yet the underlying neurochemical and molecular mechanisms remain poorly understood. This study aimed to investigate whether functional alterations in anti-NMDAR encephalitis are spatially associated with neurotransmitter receptor distributions and transcriptomic profiles, to uncover their neurochemical, molecular, and cellular signatures.

Methods: A total of 25 patients diagnosed with anti-NMDA receptor encephalitis and 30 healthy controls (HCs) were recruited in this study.

View Article and Find Full Text PDF

Posterior reversible encephalopathy syndrome (PRES) is a neuro-radiological condition characterized by vasogenic edema in the parieto-occipital brain regions. Although typically reversible, some cases result in irreversible damage, particularly with delayed treatment. This study reviews 12 autopsy-confirmed cases and presents a novel case, emphasizing neuropathological findings that challenge the assumption of reversibility.

View Article and Find Full Text PDF

Anti-NMDA receptor encephalitis following SARS-CoV-2 infection in children.

Diagn Microbiol Infect Dis

December 2025

Department of Pediatric Neurology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 1617 Riyue Avenue, Chengdu City, Sichuan Province, China. Electronic address:

Background: The purpose of this study was to report the phenomenon of anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis following novel coronavirus disease 2019 (COVID-19), to minimize misdiagnoses of this as post-COVID-19 syndrome, and to promote early identification, enabling these patients to benefit from early immunotherapy.

Methods: The study included three pediatric patients with anti-NMDA receptor encephalitis following COVID-19, treated at our hospital from July to September 2023. We collected and analyzed the clinical data from these patients, including background information, clinical presentations, laboratory examination results, imaging results, electrophysiological results, treatment, and prognosis.

View Article and Find Full Text PDF