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Background: Black transgender women endure pervasive polyvictimization (experiencing multiple forms of violence throughout the lifespan). Polyvictimization is associated with poor mental health. Black transgender women also face barriers in access to healthcare, but the extent that such barriers modify the association between polyvictimization and poor mental health has not been described using convergent mixed-methods analysis.
Methods: This convergent mixed-methods secondary analysis employs an intersectional lens and integrates two inter-related datasets to describe barriers to healthcare and the extent that such barriers modify the association between polyvictimization and mental health among Black transgender women. Investigators used survey data (n = 151 participants) and qualitative interview data (n = 19 participants) collected from Black transgender women (age 18 years and older) in Baltimore, MD and Washington, DC between 2016 and 2018. Analyses include thematic content analysis, bivariate analysis, joint display, and multivariate linear regression analysis examining mediation and moderation.
Results: Joint display illuminated three domains to describe how barriers to healthcare present among Black transgender women-Affordability, Accessibility, and Rapport and Continuity. Independent t-tests revealed significantly higher polyvictimization, Post Traumatic Stress Disorder (PTSD), and depression scores among participants who reported at least one barrier to healthcare (BHI) compared to those who reported no barriers. BHI significantly moderated and partially mediated the association between polyvictimization and PTSD symptom severity and BHI fully mediated the association between polyvictimization and depressive symptom severity-when accounting for age and location.
Discussion: Findings highlight the importance of access to healthcare in modifying the association between polyvictimization and PTSD and depression symptom severity among Black transgender women. Findings call for immediate interventions aimed at reducing barriers to healthcare and improved training for clinical providers serving Black transgender women.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202936 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269776 | PLOS |
JMIR Cancer
September 2025
Department of Health Outcomes and Biomedical Informatics, University of Florida, 1889 Museum Road, Suite 7000, Gainesville, FL, 32611, United States, 1 352 294-5969.
Background: Disparities in cancer burden between transgender and cisgender individuals remain an underexplored area of research.
Objective: This study aimed to examine the cumulative incidence and associated risk factors for cancer and precancerous conditions among transgender individuals compared with matched cisgender individuals.
Methods: We conducted a retrospective cohort study using patient-level electronic health record (EHR) data from the University of Florida Health Integrated Data Repository between 2012 and 2023.
Drug Alcohol Depend
August 2025
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Objective: To estimate the association between medical and legal gender affirmation with problematic substance use among transfeminine adults.
Methods: Data from a longitudinal cohort (The LITE Study) were analyzed (n = 1186). Participants were enrolled between March 2018 and August 2020 and followed for 2 years.
Sex Transm Dis
September 2025
Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
Background: Electronic partner notification (ePN) for sexually transmitted infections (STIs) is a promising tool for linking exposed individuals to STI testing and treatment. Statewide ePN will target rising rates of chlamydia and gonorrhea in Massachusetts (MA).
Methods: We explored implementation factors and barriers and facilitators to ePN for priority populations using the Consolidated Framework for Implementation Research.
J Acquir Immune Defic Syndr
September 2025
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Background: Anti-lesbian, gay, bisexual, transgender, and/or queer (LGBTQ+) legislation has dramatically increased in the United States. These laws limit the rights of sexual and gender minoritized (SGM) youth, but their health effects remain understudied. We estimated how a hypothetical intervention setting states to have more equitable LGBTQ+-related policies would affect individual-level pre-exposure prophylaxis (PrEP) use among SGM youth and young adults, and whether internalized stigma mediates this effect.
View Article and Find Full Text PDFPsychol Sex Orientat Gend Divers
January 2025
School of Nursing, Duke University.
This exploratory study investigated the impact of the COVID-19 pandemic on stress biomarkers and allostatic load for Black and Latina transgender women living with HIV (BLTWLH), as well as COVID-19 infection, hospitalization, and vaccination status. LITE Plus is a longitudinal cohort study of BLTWLH designed to identify pathways linking biopsychosocial stress to HIV co-morbidities. Participants were enrolled between October 2019-June 2022.
View Article and Find Full Text PDF