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To our knowledge, all existing optical coherence tomography approaches for quantifying blood flow, whether Doppler-based or decorrelation-based, analyze light that is back-scattered by moving red blood cells (RBCs). This work investigates the potential advantages of basing these measurements on light that is forward-scattered by RBCs, i.e., by looking at the signals back-scattered from below the vessel. We show experimentally that flowmetry based on forward-scattering is insensitive to vessel orientation for vessels that are approximately orthogonal to the imaging beam. We further provide proof-of-principle demonstrations of dynamic forward-scattering (DFS) flowmetry in human retinal and choroidal vessels.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580005 | PMC |
http://dx.doi.org/10.1364/OL.455475 | DOI Listing |
Retin Cases Brief Rep
September 2025
Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California of Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
Purpose: To describe a case of recalcitrant bilateral peripapillary pachychoroid syndrome (PPS) treated with high-dose (HD) intravitreal aflibercept injections.
Methods: Medical and imaging records were retrospectively evaluated. Multimodal imaging included ultra-widefield indocyanine green and fluorescein angiography and fundus autofluorescence.
Clin Ophthalmol
September 2025
Internal Medicine Department, Medical Faculty, Universitas Brawijaya, Malang, Indonesia.
Purpose: To evaluate macular vessel density using clinical parameters in patients with type 2 diabetes mellitus (DM) without retinopathy.
Patients And Methods: This cross-sectional study enrolled 32 participants (63 eyes) aged 40-60 years who met the inclusion criteria. Group 1 included 32 eyes of type 2 DM, whereas the rest had no DM.
Rev Cardiovasc Med
August 2025
Department of Cardiovascular Medicine, University Hospital Leuven, 3000 Leuven, Belgium.
Intravascular optical coherence tomography (OCT) has represented a revolutionary invasive imaging method, offering high-resolution cross-sectional views of human coronary arteries, thereby promoting a significant evolution in the understanding of vascular biology in both acute and chronic coronary pathologies. Since the development of OCT in the early 1990s, this technique has provided detailed insights into vascular biology, enabling a more thorough assessment of coronary artery disease (CAD) and the impact of percutaneous coronary intervention (PCI). Moreover, a series of recent clinical trials has consistently demonstrated the clinical benefits of intravascular imaging (IVI) and OCT-guided PCI, showing improved outcomes compared to angiography-guided procedures, particularly in cases of complex coronary pathology.
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September 2025
Division of Cardiology, Osaka Rosai Hospital, Osaka, Japan.
Background: Optical coherence tomography (OCT) with artificial intelligence (AI) has been developed.
Aims: The study aimed to evaluate the differences between AI-quantified and visual assessments.
Methods: Patients scheduled for OCT-guided percutaneous coronary intervention between September 2021 and October 2022 were included.
BMC Ophthalmol
September 2025
Department of Ophthalmology, Institute of Medicine, Tribhuvan University, B.P Koirala Lions Centre For Ophthalmic Studies, Kathmandu, Nepal.
Background: To evaluate the ganglion cell complex thickness in patients taking oral hydroxychloroquine.
Methods: In this hospital-based, cross-sectional, non-interventional, comparative study, 87 eyes of 87 patients taking hydroxychloroquine were recruited. All the patients underwent complete ophthalmological evaluation along with dilated fundus examination.