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http://dx.doi.org/10.1007/s40266-022-00956-9 | DOI Listing |
Cochrane Database Syst Rev
September 2025
Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.
Background: Opioid use disorder (OUD) is commonly treated in specialized care settings with long-acting opioid agonists, also known as opioid agonist therapy, or OAT. Despite the rise in opioid use globally and evidence for a 50% reduction in mortality when OAT is employed, the proportion of people with OUD receiving OAT remains small. One initiative to improve the access and uptake of OAT could be to offer OAT in a primary care setting; primary care clinics are more numerous, might reduce the visibility and potential stigma of receiving treatment for OUD, and may facilitate the care of other medical conditions that are unrelated to OUD.
View Article and Find Full Text PDFFront Bioeng Biotechnol
August 2025
Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Spectroscopic soft sensors are developed by combining spectral data with chemometric modeling, and offer as Process Analytical Technology (PAT) tools powerful insights into biopharmaceutical processing. In this study, soft sensors based on Raman spectroscopy and linear or partial least squares (PLS) regression were developed and successfully transferred to a filtration-based recovery step of precipitated virus-like particles (VLPs). For near real-time monitoring of product accumulation and precipitant depletion, the dual-stage cross-flow filtration (CFF) set-up was equipped with an on-line loop in the second membrane stage.
View Article and Find Full Text PDFArch Gerontol Geriatr
August 2025
School of Nursing, Faculty of Health and Social Science, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China; Research Institute for Smart Ageing (RISA), The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China; WHO Collaborating Centre for Community Health Services, Sch
Background: Older adults with cognitive impairment face significant challenges in maintaining oral health while the barriers and facilitators for implementing communitybased oral health interventions are uncertain.
Objective: To understand the barriers and facilitators for the implementation of oral health intervention among community-dwelling older adults with cognitive impairment.
Methods: Literature was searched in PubMed, CINAHL, Embase, PsycINFO, Scopus and Google Scholar.
J Am Soc Echocardiogr
September 2025
Department of Cardiology, University Hospital of Ghent, Ghent University, Ghent, Belgium.
Background: The shape of the continuous wave Doppler (CWD) envelope in functional tricuspid valve regurgitation (fTR) results from the dynamic interplay between flow, pressure gradient and impedance. Although the v-wave cut-off shape in fTR is a well-recognized feature of severe TR, the complete spectrum of TR CWD shapes across the different fTR severity ranges has not been thoroughly explored, which is the scope of the present study.
Methods: In 245 patients with fTR, TR was graded with transthoracic echocardiography using the corrected proximal isovelocity surface area method and CWD shapes were scored, both qualitatively (using visual scoring into parabolic, triangular or v-wave cut-off categories) and quantitatively using a novel Vmax/Vmean parameter and time-to-peak velocity corrected for TR duration (TTP/TRD).
Anesth Analg
September 2025
Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, Oregon.
Background: Airway management in patients with odontogenic infections presents a known challenge. The current study aims to identify factors associated with anesthesia ready time (ART) and first-attempt intubation failure (FAIF) in patients with odontogenic infections.
Methods: In a retrospective cohort study, subjects 14 years and older between January 1, 2012, and December 31, 2019, requiring incision and drainage for odontogenic infections under general anesthesia were included.