Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A polysaccharides-based delivery system was designed to encapsulate and control the release of peanut peptide (PP). The PP-loaded polyelectrolyte complex (TMC-PP-SA) was fabricated based on the electrostatic self-assembly between n-trimethy chitosan (TMC) and sodium alginate (SA). The complex exhibited uniform spherical morphology, satisfactory stability and high encapsulation efficiency. In vitro release behavior indicated that TMC-PP-SA polyelectrolyte complex could inhibit the release of PP at simulated gastric medium and enhance the release of PP at simulated intestinal medium. Moreover, the antioxidant activity of PP after encapsulation was significantly improved compared with that of directly digested PP. Ex vivo intestinal permeation study confirmed that about 41.76 ± 1.43% PP in TMC-PP-SA could be absorbed in the intestinal. The cytotoxicity measurement indicated that the fabricated TMC-PP-SA polyelectrolyte complex was biocompatible and nontoxic. Therefore, these results indicated that the polysaccharides-based delivery system had great potential in protecting active peptides from degradation and facilitating their absorption.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.carbpol.2022.119580 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Improving the colonic release and serum glucose regulation of insulin by co-loaded a prebiotic in alginate composite microcapsules.
Int J Biol Macromol
September 2025
School of Food Science and Engineering, South China University of Technology, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Guangzhou 510640, China.
Oral insulin (INS) administration can considerably enhance compliance of diabetes patients. The polysaccharides-based microbiota-triggered colon delivery system is considered to have the most potential, but successful release of INS is limited due to intestinal microbiota disturbances in diabetic patients. Therefore, this study attempts to construct a INS colon delivery system that can collaboratively improve intestinal microbiota.
View Article and Find Full Text PDFA comprehensive review on natural polysaccharides based in situ gels for nasal drug delivery.
Int J Biol Macromol
August 2025
SSR College of Pharmacy, UT of Dadra Nagar Haveli & Daman Diu, Silvassa 396230, India. Electronic address:
In situ nasal gels developed from natural polysaccharides have been recognized as a highly promising drug delivery system for the effective treatment of both systemic and localized diseases. These gels are triggered to undergo sol-to-gel transition when exposed to nasal physiological parameters like temperature, pH, or ionic strength, facilitating increased mucoadhesion, extended residence time, and enhanced bioavailability of drugs. Biocompatible and biodegradable natural polysaccharides such as chitosan, gellan gum, alginate, and pectin are the most commonly used natural polymers.
View Article and Find Full Text PDFQuercetin-polysaccharides based hydrogels: A review of applications, molecular associations, chemical and biological modifications, toxicological implications and future perspectives.
Int J Biol Macromol
July 2025
Medical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan. Electronic address:
The conventional treatments have certain demerits, while the advanced methods include stem cell therapy and nanotherapeutics using various mediums like polysaccharides-based hydrogels due to their antimicrobial action, moisture retention, and controlled delivery of drugs. The current review encompasses that quercetin-polysaccharide based hydrogels stimulate wound healing by providing sustained antioxidant activity, eliminating reactive oxygen species (ROS), and alleviating oxidative stress (OS), while inducing angiogenesis, collagen deposition, and anti-inflammatory response for rapid repair. Hydrogels also show antibacterial action and enhance bioavailability, which allows for accelerated wound closure and minimized scarring.
View Article and Find Full Text PDFInfertility treatment using polysaccharides-based hydrogels: new strategies in tissue engineering and regenerative medicine.
J Nanobiotechnology
March 2025
Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Infertility is a primary health issue affecting about 15% of couples of reproductive ages worldwide, leading to physical, mental, and social challenges. Advances in nanobiotechnology and regenerative medicine are opening new therapeutic horizons for infertility by developing polysaccharide-based nanostructured biomaterials. This review explores the role of tissue engineering and regenerative medicine in infertility treatment, explicitly focusing on the promising potential of polysaccharide-based hydrogels.
View Article and Find Full Text PDFDevelopment of agar-alginate marine polysaccharides-based hydrogels for agricultural applications to reduce environmental hazards.
Int J Biol Macromol
March 2025
Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
In order to meet global food requirement, innovation in agricultural techniques and pesticide delivery system will be required for sustainable food supply with minimal harmful impact on environment. This article discusses the synthesis of hydrogels for use in controlled release formulations (CRFs) to increase agricultural output while reducing ecotoxicity and health risks. These hydrogels were designed by graft-copolymerization reaction of polyacrylamide and polyvinyl sulfonic acid onto agar-alginate marine polysaccharides.
View Article and Find Full Text PDF