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Not much is known about FAM136A, a human gene that may be involved in Meniere's disease and is conserved throughout animals. To understand the function of , the ortholog of FAM136A, loss of function alleles of the gene were generated. We find that loss of function results in minor but significant changes to the locomotion and behavior.
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http://dx.doi.org/10.17912/micropub.biology.000553 | DOI Listing |
Immunol Invest
September 2025
Department of Function, Affiliated Wuxi Fifth Hospital of Jiangnan University, Wuxi, China.
Objective: This study aims to elucidate how butyrate, a short-chain fatty acid, regulates the Treg/Th17 balance in ulcerative colitis (UC) via the cAMP-PKA/mTOR signaling pathway, offering novel treatment strategies.
Methods: Dextran sulfate sodium (DSS) was used to induce ulcerative colitis in a mouse model. Various butyrate dosages were administered to the mice.
J Assist Reprod Genet
September 2025
Morsani College of Medicine, Department of Obstetrics and Gynecology, University of South Florida, 2 Tampa General Circle, STC 6th Floor, Tampa, FL, 33606, USA.
Purpose: Prior studies in fresh embryo transfer IVF cycles have associated elevated serum progesterone level on day of ovulatory trigger, particularly if ≥ 1.5 ng/ml, with decreased pregnancy rates. A similar association has been found in intrauterine insemination (IUI) cycles using gonadotropins for ovulation induction.
View Article and Find Full Text PDFJ Cosmet Dermatol
September 2025
School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, People's Republic of China.
Background: In recent years, the problem of female alopecia has been increasing and has shown a trend toward youthfulness. However, there are fewer studies on young female alopecia in the existing literature.
Aim: We aimed to study the possible causes of hair loss in young Chinese females aged 18-35 with oily scalps.
Pestic Biochem Physiol
November 2025
State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China. Electronic address:
Potato virus Y (PVY) is one of the most economically detrimental phytoviruses affecting global Solanaceae, possessing challenges in agrochemical control. The structural elucidation of PVY coat protein (CP) offers opportunities for the rational design of CP-targeted antivirals; however, the feasibility of identifying lead compounds via virtual screening remains largely unexplored. Herein, we report the successful case of structure-based virtual screening leveraging PVY CP, enabling the identification of a structurally novel lead with a unique mechanism of action.
View Article and Find Full Text PDF