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We investigated the spectral property changes in anti-adhesion films, which were cross-linked and surface-modified through electron beam irradiation, using terahertz time-domain spectroscopy (THz-TDS). Polyethylene oxide (PEO), which is a biocompatible and biodegradable polymer, was the main component of these anti-adhesion films being manufactured for testing. The terahertz characteristics of the films were affected by the porosity generated during the freeze-drying and compression processes of sample preparation, and this was confirmed using optical coherence tomography (OCT) imaging. An anti-adhesion polymer film made without porosity was measured by using the THz-TDS method, and it was confirmed that the refractive index and absorption coefficient were dependent on the crosslinking state. To our knowledge, this is the first experiment on the feasibility of monitoring cross-linking states using terahertz waves. The THz-TDS method has potential as a useful nondestructive technique for polymer inspection and analysis.
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http://dx.doi.org/10.3390/polym14102008 | DOI Listing |
Biomater Biosyst
September 2025
Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Dr, Saskatoon SK S7K 5A9, Canada.
Gynecologic postoperative adhesions (GPOA) remain an under-appreciated source of morbidity despite advances in minimally invasive surgery. Adhesions forming after myomectomy, extensive endometriosis excision, repeat caesarean section, or hysteroscopic adhesiolysis develop in 20 - 90 % of patients and account for up to 40 % of secondary infertility, chronic pelvic pain, bowel obstruction, and life-threatening obstetric complications such as placenta accreta spectrum. Because the uterus is hormonally responsive and destined for potential pregnancy, anti-adhesion barriers for gynecologic tissues must meet stricter criteria for biocompatibility, resorption timing, teratogenic safety, and reproductive regulatory classification than barriers designed for bowel or tendon repair.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Wenzhou Institute, Institute of Translational Medicine, Shanghai University, Shanghai 200444, China. Electronic address:
Postoperative adhesion (POA) is a common surgical issue that can cause serious secondary problems. Current clinical strategies primarily focus on preventive measures, with physical barriers being the predominant method. However, the limited adaptability and short retention of static physical barriers like films and hydrogels in dynamic physiological environments have hindered their long-term therapeutic effectiveness.
View Article and Find Full Text PDFMater Today Bio
August 2025
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China.
Postoperative anti-adhesion materials face significant challenges, including dislocation, the induction of nonspecific tissue adhesions, and secondary fibrinolytic disorders. In this study, we developed a self-leveling, transient, unilaterally bonded Janus patch (J-HD) based on hemoadhican (HD). This patch consists of three distinct functional layers: an anti-adhesion layer, a reinforcement layer, and a wet tissue adhesion layer.
View Article and Find Full Text PDFPLoS One
May 2025
Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
Since abdominal adhesion are quite problematic in abdominal and pelvic surgery, the conventional HA/CMC film are commonly used as an anti-adhesive material. However, such types are difficult to be rolled and delivered through the port of laparoscopic surgical devices due to adherence to the laparoscopic port or other parts of the films. To create an anti-adhesion film with more favorable handling properties and anti-adhesive effect, we developed a novel punctate uneven gelatin film (PU GF).
View Article and Find Full Text PDFInfect Disord Drug Targets
December 2024
Depart-ment of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Introduction: Biosurfactants are naturally occurring compounds with various ap-plications, biodegradable, non-toxic, and effective in different conditions. This study fo-cuses on the extraction and evaluation of biosurfactants produced by five strains of lactic acid bacteria [LAB] for their potential to inhibit biofilm formation and adhesion by Strep-tococcus mutans.
Methods: The strains of LAB-producing biosurfactants such as Lactobacillus salivarius, L.