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Identification and re-identification are two major security and privacy threats to medical imaging data. De-identification in DICOM medical data is essential to preserve the privacy of patients' Personally Identifiable Information (PII) and requires a systematic approach. However, there is a lack of sufficient detail regarding the de-identification process of DICOM attributes, for example, what needs to be considered before removing a DICOM attribute. In this paper, we first highlight and review the key challenges in the medical image data de-identification process. In this paper, we develop a two-stage de-identification process for CT scan images available in DICOM file format. In the first stage of the de-identification process, the patient's PII-including name, date of birth, etc., are removed at the hospital facility using the export process available in their Picture Archiving and Communication System (PACS). The second stage employs the proposed DICOM de-identification tool for an exhaustive attribute-level investigation to further de-identify and ensure that all PII has been removed. Finally, we provide a roadmap for future considerations to build a semi-automated or automated tool for the DICOM datasets de-identification.
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http://dx.doi.org/10.3390/healthcare10050755 | DOI Listing |
Nat Biotechnol
September 2025
Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.
RNA-protein interactions critically regulate gene expression and cellular processes, yet their comprehensive mapping remains challenging due to their structural diversity. We introduce PRIM-seq (protein-RNA interaction mapping by sequencing), a method for concurrent de novo identification of RNA-binding proteins and their associated RNAs. PRIM-seq generates unique chimeric DNA sequences by proximity ligation of RNAs with protein-linked DNA barcodes, which are subsequently decoded through sequencing.
View Article and Find Full Text PDFCarbohydr Res
September 2025
Laboratory for Biochemistry & Glycobiology, Ghent University, Department of Biotechnology, Ghent, Belgium. Electronic address:
Lectins are carbohydrate-binding proteins which play key roles in various biological processes, including cell signaling, pathogen recognition and development. Previous research conducted on ricin-B lectin domains and carbohydrate-binding modules of family 13 (CBM13) illustrated the striking resemblances between these two groups of protein domains. In this study, we report on the discovery, identification and putative biochemical characteristics of a ricin-B-like domain that is unique for GH27 enzymes from land plants, identified in the OsAPSE enzyme from Japanese rice (Oryza sativa L.
View Article and Find Full Text PDFJ Radiol Prot
September 2025
Centre for Radiation Protection Research, Stockholm University, Svante Arrheniusväg 20C, 106 91 Stockholm, Sweden.
The System of Radiological Protection (the "System") developed by the International Commission on Radiological Protection (ICRP) is built on nearly a century of efforts of numerous scientists and practitioners working together internationally. It rests on three enduring pillars: science, ethics, and experience. These pillars support the three fundamental principles that shape radiological protection strategies: justification, optimisation, and application of dose limits.
View Article and Find Full Text PDFNaturwissenschaften
September 2025
Laboratório de Ecologia E Conservação de Invertebrados, LECIN, Departamento de Ecologia E Conservação, Instituto de Ciências Naturais, Universidade Federal de Lavras, PO Box 3037, CEP 37.203-202, Lavras, MG, Brasil.
Fire is a key natural disturbance influencing physical, chemical, and biological processes in the Cerrado. Ash, a fire byproduct, may significantly influence soil macrofauna through its chemical properties. Dung beetles (Scarabaeinae), critical components of Cerrado soil macrofauna, provide key ecological functions and services.
View Article and Find Full Text PDFNat Protoc
September 2025
Pharmacomicrobiomics Research Center and College of Pharmacy, Hanyang University, Ansan, Republic of Korea.
Metabolism is a fundamental process that shapes the pharmacological and toxicological profiles of drugs, making metabolite identification and analysis critical in drug development and biological research. Global Natural Products Social Networking (GNPS) is a community-driven infrastructure for mass spectrometry data analysis, storage and knowledge dissemination. GNPS2 is an improved version of the platform offering higher processing speeds, improved data analysis tools and a more intuitive user interface.
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