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With the development and wide application of nickel-based single-crystal superalloys, the effect of Ru on the microstructure stability and high-temperature properties of superalloys is becoming increasingly important. In this study, the effect of Ru on the evolution of the γ' phase in Ni-Al-Ru ternary alloys during aging treatment was analyzed, using a scanning electron microscope and transmission electron microscope, combined with energy-dispersive spectroscopy. The relationship between chemical partition behavior and γ/γ' lattice misfit was investigated in detail. During the aging process, Ru addition suppressed the growth rate and rafting process of γ' precipitates, while the effect of Ru on hindering γ' phase growth was reduced when the Ru content was over 3 at%. Ru preferentially partitioned to the γ phase, and its partitioning ratio to the γ phase increased with a variation in Ru content from 1 at% to 3 at% and decreased for the NiAl6Ru alloy. Additionally, the lattice misfit of all alloys was positive and reduced with the increase in Ru content, which hindered the Ru atoms to diffuse into the γ phase and promoted the shape of γ' precipitates to change from cubic to spherical.
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http://dx.doi.org/10.3390/ma15093344 | DOI Listing |
NPJ Drug Discov
April 2025
Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.
Drug-resistant tuberculosis (TB) continues to challenge treatment options, necessitating the exploration of new compounds of novel targets. The mycobacterial respiratory complex cytochrome bc:aa has emerged as a promising target, exemplified by the success of first-in-class inhibitor Q203 in phase 2 clinical trials. However, to fully exploit the potential of this target and to identify the best-in-class inhibitor more compounds need evaluation.
View Article and Find Full Text PDFMolecules
January 2025
Department of Physics and AMRI, University of New Orleans, New Orleans, LA 70148, USA.
Royal jelly and medical grade honey are traditionally used in treating wounds and infections, although their effectiveness is often variable and insufficient. To overcome their limitations, we created novel amphiphiles by modifying the main reparative and antimicrobial components, queen bee acid (hda) and 10-hydroxyl-decanoic acid (hdaa), through peptide bonding with specific tripeptides. Our molecular design incorporated amphiphile targets as being biocompatible in wound healing, biodegradable, non-toxic, hydrogelable, prohealing, and antimicrobial.
View Article and Find Full Text PDFAntimicrob Agents Chemother
January 2025
Center for TB Research, Johns Hopkins University, Baltimore, Maryland, USA.
The clinical efficacy of combination drug regimens containing the first-generation diarylquinoline (DARQ) bedaquiline in the treatment of multidrug-resistant tuberculosis has validated ATP synthesis as a vulnerable pathway in . New DARQs in clinical development may be even more effective than bedaquiline, including against emerging bedaquiline-resistant strains. Telacebec (T) is a novel cytochrome bc:aa oxidase inhibitor that also inhibits ATP synthesis.
View Article and Find Full Text PDFCurr Microbiol
November 2024
Key Laboratory of Resources Biology and Biotechnology in Western China, College of Life Sciences, Ministry of Education, Northwest University, Xi'an, China.
Our previous studies identified PA5407 in Pseudomonas aeruginosa as a new regulatory protein for bacterial division and named it ZapAL. This protein enhances the assembly of the key bacterial division protein FtsZ and participates in the assembly of the bacterial Z-ring, but its physiological function is not clear. ZapAL is in the same gene cluster as PA5402-5406, and in this study, we found that these genes are involved in the regulation of bacterial growth under nutrient deficiency and high-density conditions.
View Article and Find Full Text PDFJ Biomol Struct Dyn
April 2025
Department of Pharmaceutical Sciences, School of Health Sciences and Technology, UPES, Dehradun, Uttarakhand, India.
The cytochrome supercomplex, a key component in the electron transport chain pathway involved in bacterial energy production and homeostasis, is a clinically validated target for tuberculosis (TB), leading to Telacebec (Q203). Telacebec is a potent candidate drug under Phase II clinical development for the treatment of drug-sensitive and drug-resistant TB. Recently, the cryo-electron microscopy structure of this supercomplex from (Mtb) complexed with Q203 was resolved at 6.
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