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Metabolic syndrome (MetS) is characterized by the concurrence of multiple metabolic disorders resulting in the increased risk of a variety of diseases related to disrupted metabolism homeostasis. The prevalence of MetS has reached a pandemic level worldwide. In recent years, extensive amount of data have been generated throughout the research targeted or related to the condition with techniques including high-throughput screening and artificial intelligence, and with these "big data", the prevention of MetS could be pushed to an earlier stage with different data source, data mining tools and analytic tools at different levels. In this review we briefly summarize the recent advances in the study of "big data" applications in the three-level disease prevention for MetS, and illustrate how these technologies could contribute tobetter preventive strategies.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095427 | PMC |
http://dx.doi.org/10.3389/fgene.2022.810152 | DOI Listing |
Ann Lab Med
September 2025
Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
BMJ Health Care Inform
September 2025
Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
Objectives: The objectives were to examine the associations between accelerometer-measured circadian rest-activity rhythm (CRAR), the most prominent circadian rhythm in humans and the risk of mortality from all-cause, cancer and cardiovascular disease (CVD) in patients with cancer.
Methods: 7456 cancer participants from the UK Biobank were included. All participants wore accelerometers from 2013 to 2015 and were followed up until 24 January 2024, with a median follow-up of 9.
Cell Signal
September 2025
Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No. 81 Meishan Road, Hefei 230032, Anhui, China; Engin
Leber's hereditary optic neuropathy (LHON), a mitochondrial disorder marked by central vision loss, exhibits incomplete penetrance and male predominance. Since there are no adequate models for understanding the rapid vision loss associated with LHON, we generated induced pluripotent stem cells (iPSCs) from LHON patients carrying the pathogenic m.3635G > A mutation and differentiated them into retinal pigment epithelium (RPE) cells.
View Article and Find Full Text PDFToxicol Lett
September 2025
Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea; Institute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea. Electronic address:
Environmental phenols are widely used in consumer products and are of increasing concern due to their potential endocrine-disrupting effects. Physiologically based toxicokinetic (PBTK) models offer a powerful tool for estimating human exposure by translating biomonitoring data into external intake values. However, conventional PBTK models are typically chemical-specific and resource-intensive.
View Article and Find Full Text PDFAm J Clin Nutr
September 2025
Department of Geriatrics, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou 3100003, China. Electronic address:
Background: Muscle quality index (MQI), a new metric for assessing sarcopenia, reflects the functional capacity of muscle. However, the associations between MQI and adverse health outcomes and the corresponding mechanisms are not well understood.
Objective: We aimed to prospectively evaluate the associations of MQI with risk of nine adverse health outcomes (ie, osteoarthritis, cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), respiratory disease, chronic kidney disease (CKD), liver disease, dementia, depression, and all-cause mortality), as well as the mediating role of metabolomics in these associations.