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Hairy cell leukaemia (HCL) is a rare B cell malignancy with an indolent course leading to pancytopaenia due to bone marrow infiltration. It has been proposed that HCL patients are at risk of developing a secondary malignancy, with a marked likelihood of the development of other hematologic malignancies including Hodgkin lymphoma and high-grade non-Hodgkin lymphomas. Here, we present the case of two patients who developed diffuse large B cell lymphoma after a long course of hairy cell leukaemia. In the case of the female patient, we report on the occurrence of a third malignant disease, which is very uncommon. With our case descriptions we contribute to the very small number of similar cases reported.
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http://dx.doi.org/10.3389/pore.2022.1610338 | DOI Listing |
Philos Trans A Math Phys Eng Sci
September 2025
Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada.
Flagellates, unicellular organisms equipped with one or a few flagella, are phylogenetically and functionally hugely diverse. Yet, most studies have focused on a few model organisms and on the role of the flagellum in propulsion, ignoring the fundamental role of the flagellum in foraging. The number and position of flagella vary between species; the flagella may be naked or equipped with vanes or hairs; the kinematics and wave patterns vary and may be planar or three-dimensional; and the flagellum may extend from the surface of the cell or lie within a groove on the cell surface.
View Article and Find Full Text PDFSignal Transduct Target Ther
September 2025
Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Essential tremor (ET) is a common neurological disease that is characterized by 4-12 Hz kinetic tremors of the upper limbs and high genetic heterogeneity. Although numerous candidate genes and loci have been reported, the etiology of ET remains unclear. A novel ET-related gene was initially identified in a five-generation family via whole-exome sequencing, and other variants were identified in 772 familial ET probands and 640 sporadic individuals via whole-genome sequencing.
View Article and Find Full Text PDFItal J Dermatol Venerol
August 2025
Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy.
Arterioscler Thromb Vasc Biol
September 2025
Department of Cardiology, Laboratory of Heart Center, Heart Center, Zhujiang Hospital, Southern Medical University, China. (Q.D., X.Z., L.F., A.C., Z.L., Y.Y., J.Z., X.L., Y.L., J.Y.).
Background: Vascular calcification is very common in patients with chronic kidney disease and contributes to the increased risk of cardiovascular events. NAMPT (nicotinamide phosphoribosyltransferase), the rate-limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide, has been shown to exert an antiaging effect on vascular smooth muscle cells. However, whether NAMPT is involved in the regulation of vascular calcification remains unclear.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Hematology, Jiaozuo People's Hospital, Jiaozuo, Henan, China.
Hairy cell leukemia variant (HCL-v) is a rare and more aggressive subtype of B-cell leukemia. While it shares certain clinical features with classical hairy cell leukemia (HCL-c), HCL-v typically follows a more malignant course and responds poorly to conventional therapies. We report a case of HCL-v in a 57-year-old male who was admitted with splenomegaly and abnormal blood counts.
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