Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Innate lymphoid cells (ILCs) are a family of immune cells that possess similar functions as T cells. We review steps of central ILC development in the bone marrow of adult mice and discuss recent evidence for peripheral ILC development suggesting extramedullary sites of ILC development. We also assess the contribution of development during different phases of life towards shaping the composition of the adult ILC pool. Finally, we briefly review the local cues that lead to heterogeneity of ILCs between tissues. We propose that tissue-resident ILC progenitors may economically allow tissues to elicit rapid expansion of specific ILC types that are needed based on the nature of antigenic assaults in tissues.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-981-16-8387-9_2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Breast cancer is a heterogeneous disease with numerous histological subtypes. Invasive lobular cancer (ILC) is the most common special subtype, accounting for 10-15% of all breast cancers. The pathognomonic feature of ILC is the loss of E-cadherin (CDH1), which leads to a unique single-file growth pattern of discohesive cells.
View Article and Find Full Text PDFTriple-negative invasive lobular carcinoma presenting with synchronous gastric metastasis: A case report.
Oncol Lett
November 2025
Department of Oncology, Nanjing Gaochun People's Hospital, Jiangsu, Nanjing 211300, P.R. China.
Triple-negative invasive lobular carcinoma (TN-ILC) is a rare and highly aggressive subtype of breast cancer. The development of gastric metastases in breast cancer is extremely rare and typically occurs several years after initial diagnosis. The present case report describes a 68-year-old postmenopausal female patient who presented with TN-ILC with gastric metastases at initial diagnosis.
View Article and Find Full Text PDFCellular Cosmetics: How Innate Lymphoid Cells Can Recontour the Tumour Microenvironment.
Eur J Immunol
September 2025
Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
The innate lymphoid cell (ILC) family includes natural killer (NK) cells, recognised for over 50 years, as well as several more recently identified populations. Over the past 15 years, ILCs have emerged as key orchestrators of tissue homeostasis and inflammation. To build upon the early promise of cancer immunotherapies, it is essential to better understand the pathways regulating the composition of, and immunosuppressive mechanisms that dominate many solid cancers and effectively curtail or block T cell responses.
View Article and Find Full Text PDFDissecting the heterogeneity and tumor-associated dynamics of human liver group I ILC via scRNA sequencing data.
Immunol Res
August 2025
Institute of Medical Engineering & Translational Medicine, Tianjin University, Tianjin, 300072, China.
Single-cell transcriptome analysis has made outstanding contributions to the identification of new cell lineages and the study of cancer immune microenvironment. Yet, the characterization of human liver type 1 innate lymphoid cells (ILC1s) and their dynamic changes in the tumor microenvironment have not been thoroughly studied at this detailed level. Here, we performed an integrated analysis of mouse and human liver immune cells to identify human liver ILC1s based on identified mouse liver ILC1s and to verify its functional similarity.
View Article and Find Full Text PDFInvasive lobular carcinoma: Strategies and perspectives from the lobular breast cancer research group.
Cancer Treat Rev
August 2025
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, the United States of America. Electronic address:
Invasive lobular carcinoma (ILC) represents approximately 10-15% of all breast cancers and is defined by a unique discohesive morphology due to loss of E-cadherin. Despite its prevalence, ILC has been historically underrepresented in clinical and translational research, contributing to diagnostic, therapeutic, and prognostic uncertainties. This narrative review, conducted by the Invasive Lobular Carcinoma Research Group, synthesizes current evidence on ILC with expert perspectives to inform future research and clinical strategies.
View Article and Find Full Text PDF