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Article Abstract
A facile transition-metal-free protocol to form 2-iminoimidazo[1, 2-]-pyridines bearing a -CHBr group and an aza-quaternary carbon center at the 3 position from -(2-pyridyl)amidines substrates, in which the new heterocyclic skeletons constructed from amidines radical reactions or nucleophilic substitution reactions are promoted only by CBr under mild conditions, is demonstrated. The reactions were realized by intramolecular CDC reaction involving C-N and C-C bond formation the sequential C(sp)-H bifunctionalization mode on the same carbon atom under mild conditions. Moreover, this work also provides an excellent and representative example for CBr as an efficient reagent to initiate radical reactions under initiator-free conditions or to give rise to nucleophilic substitution reactions only by base.
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| http://dx.doi.org/10.1039/c9ra09265j | DOI Listing |
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