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Background: Despite substantial resources deployed to curb SARS-CoV-2 transmission, controlling the COVID-19 pandemic has been a major challenge. New variants of the virus are frequently emerging leading to new waves of infection and re-introduction of control measures. In this study, we assessed the effectiveness of containment strategies implemented in the early phase of the pandemic.
Methods: Real-world data for COVID-19 cases was retrieved for the period Jan 1 to May 1, 2020 from a number of different sources, including PubMed, MEDLINE, Facebook, Epidemic Forecasting and Google Mobility Reports. We analyzed data for 18 countries/regions that deployed containment strategies such as travel restrictions, lockdowns, stay-at-home requests, school/public events closure, social distancing, and exposure history information management (digital contact tracing, DCT). Primary outcome measure was the change in the number of new cases over 30 days before and after deployment of a control measure. We also compared the effectiveness of centralized versus decentralized DCT. Time series data for COVID-19 were analyzed using Mann-Kendall (M-K) trend tests to investigate the impact of these measures on changes in the number of new cases. The rate of change in the number of new cases was compared using M-K z-values and Sen's slope.
Results: In spite of the widespread implementation of conventional strategies such as lockdowns, travel restrictions, social distancing, school closures, and stay-at-home requests, analysis revealed that these measures could not prevent the spread of the virus. However, countries which adopted DCT with centralized data storage were more likely to contain the spread.
Conclusions: Centralized DCT was more effective in containing the spread of COVID-19. Early implementation of centralized DCT should be considered in future outbreaks. However, challenges such as public acceptance, data security and privacy concerns will need to be addressed.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052634 | PMC |
http://dx.doi.org/10.1016/j.jiph.2022.04.012 | DOI Listing |
PLoS Med
September 2025
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Background: Limited mpox vaccination coverage, declining cross-protection from historical smallpox vaccination campaigns, and persistent zoonotic reservoirs leave many sub-Saharan countries susceptible to mpox outbreaks. With millions of vaccine doses made available to the region since late 2024 and the absence of country-specific guidelines for allocation, estimating the country-specific impact of one-time mass vaccination strategies is necessary for ongoing outbreaks and other countries at future risk.
Methods And Findings: We adapted a next generation matrix model to project disease transmission potential for 47 sub-Saharan countries from 2025 to 2050 under four transmission scenarios with different contributions of community versus sexual contacts.
Sci Total Environ
September 2025
Sustainable Use, Management and Reclamation of Soil and Water Research Group, Universidad Politécnica de Cartagena, Paseo Alfonso XIII 48, 30203 Cartagena, Spain. Electronic address:
Mining areas are highly susceptible to environmental contamination due to the accumulation of potentially toxic elements (PTEs), necessitating regular monitoring to assess environmental risks. In this study, soil samples were collected from two depths (0-15 cm and 15-30 cm) at 74 stations, along with deep waste samples (0-12 m) from three adjacent tailings ponds in the Mazarrón mining area, Spain. Soil/waste physicochemical properties and the Cd, Cu, Zn, and Pb concentrations of total, water-soluble, and bioavailable fractions were analyzed.
View Article and Find Full Text PDFAnn Med Surg (Lond)
September 2025
Department of Biomedical and Laboratory Science, Africa University, Mutare, Zimbabwe.
Neutrophils, the most abundant innate immune cells, play a complex role in human immunodeficiency virus (HIV) infection, balancing between protective immunity and pathogenic inflammation. Initially, neutrophils contribute to early viral containment through phagocytosis, reactive oxygen species (ROS) production, and neutrophil extracellular traps (NETs). However, their excessive activation in chronic HIV infection can lead to systemic inflammation, immune dysfunction, and tissue damage.
View Article and Find Full Text PDFInd Eng Chem Res
August 2025
Department of Process Engineering and Applied Science, Dalhousie University, P.O. Box 15000, Halifax, Nova Scotia B3H 4R2, Canada.
The technology readiness of chemical looping is rapidly being advanced by transforming batch-mode bench-scale systems into continuously or semicontinuously operating pilot units, and these changes in operating modes and scales introduce new levels of risk. To ensure pilot plants operate in a safe and successful manner and to sustain public support and a positive perception, it is important that a rigorous process safety approach is implemented in both the design and the operations stages of facilities, especially with limited operating history at larger scales. Beyond the application of technically sound engineering of individual unit operations, additional considerations are required for safer operations.
View Article and Find Full Text PDFTrop Med Health
September 2025
RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.
Background: Schistosomiasis is a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma. Currently, praziquantel is the only medication available for treating schistosomiasis. However, crucial issues regarding drug resistance, reinfection, and prevention remain unresolved.
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