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http://dx.doi.org/10.1039/c9ra90001b | DOI Listing |
J Adv Nurs
September 2025
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Aims: To assess self-reported practices and knowledge of nurses and prescribers (i.e., physicians and nurse practitioners) on intravenous fluid therapy, and to evaluate how this is documented through a clinical documentation review.
View Article and Find Full Text PDFTher Hypothermia Temp Manag
September 2025
University Hospital of Wales, Cardiff, Wales, United Kingdom.
The critical care unit at the University Hospital of Wales is a 38-bedded tertiary center. In 2023, the unit admitted 1251 unscheduled patients, of which 131 were out-of-hospital cardiac arrest (OOHCA) patients. The unit also participated in the Targeted Temperature Management 2 study and adopted the findings shortly after its publication in 2021.
View Article and Find Full Text PDFAnal Methods
September 2025
College of Science, Kunming University of Science and Technology, Kunming, 650500, China.
To address the technical challenges associated with determining the chronological order of overlapping stamps and textual content in forensic document examination, this study proposes a novel non-destructive method that integrates hyperspectral imaging (HSI) with convolutional neural networks (CNNs). A multi-type cross-sequence dataset was constructed, comprising 60 samples of handwriting-stamp sequences and 20 samples of printed text-stamp sequences, all subjected to six months of natural aging. Spectral responses were collected across the 400-1000 nm range in the overlapping regions.
View Article and Find Full Text PDFBrain Behav
September 2025
School of Pharmacy and Medical Technology, Putian University, Putian, China.
Background: Recent research has started to uncover an important connection between immune system activity and cognitive abilities. Although correlative associations have been documented, the causal mechanisms connecting specific immune cell subpopulations to cognitive capabilities remain insufficiently characterized. Our research aimed to determine directional relationships between distinct immune cell subtypes and cognitive function, potentially identifying targets for immunomodulatory interventions.
View Article and Find Full Text PDFBiom J
October 2025
Novella Clinical Full Service, IQVIA, Melbourne, Australia.
Phase I dose escalation trials in oncology generally aim to find the maximum tolerated dose. However, with the advent of molecular-targeted therapies and antibody drug conjugates, dose-limiting toxicities are less frequently observed, giving rise to the concept of optimal biological dose (OBD), which considers both efficacy and toxicity. The estimand framework presented in the addendum of the ICH E9(R1) guidelines strengthens the dialogue between different stakeholders by bringing in greater clarity in the clinical trial objectives and by providing alignment between the targeted estimand under consideration and the statistical analysis methods.
View Article and Find Full Text PDF