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http://dx.doi.org/10.1111/epi.17272 | DOI Listing |
J Crohns Colitis
September 2025
Université de Paris, INSERM U1342, Institut de Recherche Saint-Louis, Paris, France.
Background And Aims: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), remain heterogeneous disorders with variable response to biologics. Post-operative recurrence in CD is common despite surgery and prophylactic biotherapies. Understanding the inflammatory mediators associated with recurrence and treatment response could pave the way for personalized strategies.
View Article and Find Full Text PDFCancer Immunol Res
September 2025
University of Pennsylvania, Philadelphia, PA, United States.
Pancreatic ductal adenocarcinoma (PDA) is defined by a myeloid-enriched microenvironment and has shown remarkable resistance to immune checkpoint blockade (e.g., PD-1 and CTLA-4).
View Article and Find Full Text PDFEur J Neurol
September 2025
Department of Neuroscience 'Rita Levi Montalcini', University of Torino, Torino, Italy.
Background: The factors contributing to a poor response to subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) are not yet fully understood. Accordingly, predicting the outcome might be challenging particularly in those who display an optimal response to the Levodopa challenge test.
Objective: To determine which factors may contribute to poor outcome of STN-DBS in PD.
J Integr Neurosci
August 2025
School of Computer Science, Guangdong Polytechnic Normal University, 510665 Guangzhou, Guangdong, China.
Background: Emotion recognition from electroencephalography (EEG) can play a pivotal role in the advancement of brain-computer interfaces (BCIs). Recent developments in deep learning, particularly convolutional neural networks (CNNs) and hybrid models, have significantly enhanced interest in this field. However, standard convolutional layers often conflate characteristics across various brain rhythms, complicating the identification of distinctive features vital for emotion recognition.
View Article and Find Full Text PDFBlood Neoplasia
November 2025
Section of Hematology/Oncology, The University of Chicago, Chicago, IL.
Modern multiple myeloma treatment enables deep and sustained responses, necessitating assessment of minimal residual disease (MRD) in the bone marrow to refine response categorization. Recently, mass spectrometry (MS)-based methods have emerged as highly sensitive tools for measuring MRD in the peripheral blood. However, the role specific MS techniques play in response categorization has yet to be established.
View Article and Find Full Text PDF