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http://dx.doi.org/10.1038/s41591-022-01774-7 | DOI Listing |
Mol Divers
September 2025
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, Xinjiang, China.
Aurora kinases are a group of serine/threonine kinases essential for cell mitosis, comprising Aurora A, B, and C. However, the Aurora B is overexpressed in multiple tumors and the aurone has been proved to exhibit potent inhibitory activity against Aurora B kinase by our group. The indolinone was considered as an aurone scaffold hopping analog, and the indolinone-based Aurora B inhibitor library (3577 molecules) was constructed by FBDD strategy.
View Article and Find Full Text PDFDrugs Aging
September 2025
Dalla Lana School of Public Health, University of Toronto, V1 06, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
Background And Objectives: Older adults living with dementia are a heterogeneous group, which can make studying optimal medication management challenging. Unsupervised machine learning is a group of computing methods that rely on unlabeled data-that is, where the algorithm itself is discovering patterns without the need for researchers to label the data with a known outcome. These methods may help us to better understand complex prescribing patterns in this population.
View Article and Find Full Text PDFOne Health
December 2025
School of Public Health, University of Alberta, 1405 87 Ave NW, Edmonton, Alberta T6G 1C9, Canada.
Clams are an important country food with cultural, environmental, and health significance for Inuit communities in Nunavut. We analyzed the extent, range, and nature of published research on clams in Nunavut, Canada. We used a systematic and transparent scoping review methodology by applying a search string across three databases to identify potentially relevant articles.
View Article and Find Full Text PDFJ Public Health Policy
September 2025
Carrera de Medicina, Universidad Nacional de Loja, Av. Pio Jaramillo Alvarado, 110150, Loja, Ecuador.
Poor quality obstetric care can harm women's mental health, especially after childbirth. This study examines how the perceived quality of health services during childbirth is related to postpartum depression in Ecuador. Using data from 16,451 women in the 2018 National Health and Nutrition Survey, we applied probit and latent class probit models.
View Article and Find Full Text PDF