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http://dx.doi.org/10.1097/BS9.0000000000000100 | DOI Listing |
BMC Med
August 2025
Mouse Imaging Centre, Hospital for Sick Children, Toronto, Canada.
Background: Antiretroviral therapy (ART) has dramatically reduced perinatal HIV transmission, leading to a growing population of children who are HIV-exposed but uninfected (CHEU). While the neuroanatomic developmental impacts of in utero HIV and ART exposure have been studied in young children, long-term effects on school-aged children are poorly understood, prompting this investigation.
Methods: Fifty-eight CHEU and 38 children who are HIV-unexposed, uninfected (CHUU), 6-12 years old, were recruited through hospitals and community groups in Ontario, Canada.
Front Pharmacol
July 2025
Department of Thoracic Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Background: Spread through air spaces (STAS) represents a novel invasion mechanism in adenocarcinoma that considerably influences lung cancer clinical outcomes; however, studies of its mechanisms at the spatial level are lacking.
Methods: We used the NanoString GeoMx digital spatial profiling (DSP) technology to conduct a spatial transcriptomic analysis of surgically resected tissues from non-small-cell lung cancer (NSCLC) patients with or without STAS.
Results: Compared with tumor nests in non-STAS patients, and were significantly less expressed in compartments of STAS, suggesting their inhibitory roles in the occurrence of STAS.
Biol Psychol
July 2025
University of Tübingen, Tübingen, Germany.
The N400 is a central electrophysiological event-related-potential (ERP) marker thought to reflect meaning comprehension in the human brain. Typically, the N400 is larger when a word does not fit into a specific context (e.g.
View Article and Find Full Text PDFJ Natl Cancer Cent
April 2025
Department of Hematology and Oncology, Chongqing University Cancer Hospital, Chongqing, China.
Background: Human immunodeficiency virus (HIV)-associated lymphomas (HAL), mainly aggressive B-cell lymphomas, pose a significant challenge in cancer research due to their multifaceted pathogenesis and aggressive clinical course. Despite the clinical importance, the genomic and immune characteristics of these lymphomas remain poorly elucidated.
Methods: We employed single-cell RNA sequencing (scRNA-seq) on lymph node samples from aggressive B-cell lymphomas, mainly including 6 cases of diffuse large B-cell lymphoma (DLBCL) and 5 cases of Burkitt lymphoma (BL) from people living with HIV (PLWH), along with 3 DLBCL cases from individuals without HIV for comparison.
Biomedicines
June 2024
Drug Development Unit (DDU), STALICLA SA, Campus Biotech Innovation Park, Avenue de Sécheron 15, 1202 Geneva, Switzerland.
This study aimed to evaluate the safety and tolerability of STP1, a combination of ibudilast and bumetanide, tailored for the treatment of a clinically and biologically defined subgroup of patients with Autism Spectrum Disorder (ASD), namely ASD Phenotype 1 (ASD-Phen1). We conducted a randomized, double-blind, placebo-controlled, parallel-group phase 1b study with two 14-day treatment phases (registered at clinicaltrials.gov as NCT04644003).
View Article and Find Full Text PDF