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Objectives: To evaluate the use of temporary-permanent pacemaker (TPP) in patients with right bundle branch block (RBBB) undergoing transcatheter aortic valve replacement (TAVR). We also sought to identify key predictors of permanent pacemaker (PPM) within 30 days of TAVR in this population.
Background: RBBB is a well-recognized risk factor for PPM post TAVR. TPP provides stable transient pacing and reduces the need for critical care beds.
Methods: This is a retrospective chart review of 371 patients who underwent TAVR at our institution. All patients with pre-existing RBBB had TPP placed prior to TAVR (n = 37). The primary outcome was the need for critical care beds. Multivariate logistic regression analysis was performed to identify predictors of PPM within 30 days of TAVR.
Results: 67 patients required PPM within 30 days of TAVR, and 56 implanted before discharge. 51% (19 out of 37) of TPP group required PPM before discharge compared to 11% (37 out of 334) of No TPP (p < 0.001), yet TPP group spent significantly fewer hours in a critical care bed (19 vs 28 h, p = 0.01). Length of membranous septum (LMS) <8.49 mm was the strongest independent predictor of PPM within 30 days of TAVR (RAUC of 0.80, Sensitivity 0.7 and Specificity 0.8) and 98% of patients with LMS < 7 mm required PPM within 30 days.
Conclusion: TPP-TAVR is a well-defined multidisciplinary protocol that reduces the need for critical care beds in patients with pre-existing RBBB referred for TAVR. Additionally, LMS is the strongest predictor of PPM implantation in this population. CONDENSED ABSTRACT (100 WORDS): This study evaluated the use of temporary-permanent pacemakers (TPP) in patients with right bundle branch block (RBBB) undergoing transcatheter aortic valve replacement (TAVR). TPP-TAVR provided stable pacing allowing for early mobilization and reduced the need for critical care beds. Multivariate logistic regression analysis identified length of membranous septum (LMS) <8.49 mm in patients with RBBB as the strongest independent predictor of PPM need within 30 days of TAVR. 98% of patients with RBBB and LMS < 7 mm required PPM at 30 days regardless of other characteristics including valve type and size.
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http://dx.doi.org/10.1016/j.carrev.2022.03.018 | DOI Listing |
Comp Biochem Physiol C Toxicol Pharmacol
September 2025
Department of Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu, India. Electronic address:
Excessive fluoride (F) exposure, particularly during early development, poses a significant risk to skeletal integrity by disrupting bone homeostasis through oxidative stress and altered mineralization. While F induced oxidative stress is well documented, studies investigating the role of natural antioxidants in mitigating F induced osteochondral toxicity remains limited. Hence, the present study investigated the osteomodulatory effect of fisetin (Fis) against F toxicity in zebrafish larvae.
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Key Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization of Ministry of Agriculture and Rural Affairs, College of Food and Nutrition, Anhui Agricultural University, Hefei, 230036, China. Electronic address:
In this study, aloe emodin and β-d-glucose pentaacetate were added into potato starch/polyvinyl alcohol for the construction of colorimetric/fluorescent dual-pass intelligent response labels. Inspired by the lotus leaf structure, retained the advantages of the label itself and solved the hydrophilic problem of the label, and further developed a multi-functional dual-channel smart label with hydrophobicity and self-adhesion. The water contact angle of the prepared T-AEB label was 120.
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September 2025
Institute for Workflow-Management in Health Care, European University of Applied Sciences, Cologne, Germany.
In patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) who are either refractory to first-line therapy or relapse within 12 months, chimeric antigen receptor (CAR) T-cell therapy is more effective than salvage chemotherapy followed by high-dose chemotherapy and autologous stem cell transplantation (ASCT) as second-line therapy. Adoption of CAR T-cell therapy into routine clinical practice involves a period of adaptation and refinement of clinical processes. We aimed to document the evolution of clinical processes for CAR T-cell therapy during 2022 and 2023, and compare healthcare resource utilization (HCRU) associated with CAR T-cell and ASCT processes in routine clinical practice.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
September 2025
School of Agricultural Sciences, University of Thessaly, Phytokou Str Nea Ionia, Magnesia, Volos, 38446, Greece.
This investigation assessed the insecticidal efficacy of two graphene formulations (Gr1 and Gr2) on wheat kernels against adults of Sitophilus oryzae (L.) (Coleoptera: Curculionidae) and Oryzaephilus surinamensis (L.) (Coleoptera: Silvanidae) in relation to temperature and relative humidity (RH) at concentrations of 500 and 1000 ppm.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Institute for Energy Research (School for Future Technology), School of the Environment and Safety Engineering, Research Center of Fluid Machinery Engineering and Technology, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
The detection of hydrogen sulfide (HS) in humid environments remains a significant challenge, particularly in wearable gas sensors where humidity, mechanical flexibility, and power consumption are critical constraints. In this study, we introduce a stretchable, humidity-resistant HS sensor based on microcrumpled SnO quantum-wire films, designed for efficient gas detection at room temperature with low-power consumption. The sensor's architecture enhances gas adsorption by increasing the active surface area while minimizing water accumulation through surface energy modulation.
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