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The stigma of infertility negatively affects health, resulting in mental distress and poor quality of life. An appropriate scale is essential to examine the stigma experienced by infertile women and provide adequate interventions. Therefore, we developed a Japanese version of the Infertility Stigma Scale (ISS). After examining the content validity of this scale, we conducted an online survey of women undergoing fertility treatment to test the scale’s structural validity, internal consistency, intra-rater reliability, known-groups validity, convergent validity, and discriminant validity. A total of 254 participants were included in the analysis. The results of confirmatory factor analysis of four factors based on the original scale revealed the optimal fit. Cronbach’s alpha was 0.95 for the total score. Concerning test−retest analysis, the total score of the ISS and subscale had a high Spearman correlation coefficient (ρ = 0.61−0.88, p < 0.001). For convergent validity, the association between the ISS and social support, self-esteem, and family functioning was significantly negatively correlated. The results of the multitrait scaling analysis scale showed that correlations of all items exceeded 0.40, and scaling errors (7/81, 8.6%) were few. The Japanese version of the ISS was confirmed to have acceptable reliability and validity.
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http://dx.doi.org/10.3390/healthcare10030505 | DOI Listing |
J Dermatol
September 2025
Department of Dermatology, Shizuoka Cancer Center, Shizuoka, Japan.
Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in patients with advanced malignant melanoma (MM). However, more than half of patients receiving anti-programmed cell death protein-1 (PD-1) antibody monotherapy still fail to respond, with response rates varying by race and melanoma subtype. Additionally, immune-related adverse events (irAEs) remain a major concern.
View Article and Find Full Text PDFDrugs Aging
September 2025
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University (Ohashi Medical Center), Tokyo, Japan.
Interleukin (IL)-6 plays a central role in amplifying inflammation, and its inhibition is beneficial in managing immune-mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis (RA). IL-6 signaling inhibition is associated with a slightly increased risk of infections in patients with RA, and older age has been identified as a risk factor for severe adverse events, including infections. Therefore, the combination of an aging population and the increasing use of IL-6R inhibitors in RA treatment highlights the importance of carefully evaluating the safety and effectiveness of these therapies in older patients with RA.
View Article and Find Full Text PDFAppl Neuropsychol Adult
September 2025
Department of Occupational Therapy, School of Health Sciences, International University of Health and Welfare, Tochigi, Japan.
Early detection is a critical issue in dementia prevention. This study utilizes intra-individual variability in reaction time (IIV-RT) as an indicator of cognitive function. By analyzing data over a one-year period, we examine the association between IIV-RT and the Japanese version of the Montreal Test of Cognitive Abilities (MoCA-J), a cognitive screening test.
View Article and Find Full Text PDFImportance: As healthcare costs continue to rise, high-income countries-including Japan-face the urgent task of reducing healthcare spending incurred by low-value care. However, evidence is limited as to which low-value care services contribute most to unnecessary healthcare spending outside of the United States.
Objective: To identify which low-value care services contribute the most to unnecessary healthcare spending in Japan.
J Reprod Infant Psychol
September 2025
Perinatal Mental Health Unit, Hospital Clínic de Barcelona, Barcelona, Spain.
Aims/background: The present study aims to address the limitations of previous Spanish validation studies of the Postpartum Bonding Questionnaire (PBQ), including limited diagnostic range and clinical severity, and inconsistent factor structures. Specifically, the aim of this further validation is twofold: to evaluate the factor structure of the PBQ in a sample of Spanish mothers to determine a replicable structure, and to validate the Spanish version of both the full PBQ (25 items) and a reduced 14-item version (PBQ14), in a sample of mothers with and without bonding disorders, including a broader range of bonding issues and more severe cases than in previous Spanish validations.
Design/methods: Data were collected from two independent samples of mothers.