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Recovering critical raw materials from end-of-life batteries is mandatory to limit the need of virgin resources in the long-term. However, most of the recycling of lithium-ion batteries (LIBs) technologies are still in an infancy stage. As a result, to date, only few studies focus on Life Cycle Assessment (LCA) of the proposed processes, presenting limited results. This paper reports the methodology and data resulting from sustainability evaluation of 33 different technologies for spent LIBs recovery, on the basis of the availability of information, identified in literature. The ESCAPE (standing for Evaluation of Sustainability of material substitution using CArbon footPrint by a simplified approach) method is based on the use of only two parameters: the embodied energy and the carbon footprint. These parameters are calculated for all the process steps of each technology. Using the ESCAPE approach, the data about energies and emissions associated with the electricity consumption for thermal and mechanical treatments and chemicals and water use are calculated for all the 33 selected technologies, referring to a recent work (Fahimi et a., 2022), which only presents the results. In addition, ESCAPE tool is used to evaluate and discuss the parameters that can affect the technologies sustainability, to better highlight the most onerous and impactful steps of each technology. Then, this paper also shows that ESCAPE approach allows to propose some strategies to improve the recovery processes, with the aim to support eco-design.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933528 | PMC |
http://dx.doi.org/10.1016/j.dib.2022.108018 | DOI Listing |
J Virol
September 2025
Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Unlabelled: There is a need for the development of broad-spectrum antiviral compounds that can act as first-line therapeutic countermeasures to emerging viral infections. Host-directed approaches present a promising avenue of development and carry the benefit of mitigating risks of viral escape mutants. We have previously found the SKI (super killer) complex to be a broad-spectrum, host-target with our lead compound ("UMB18") showing activity against influenza A virus, coronaviruses, and filoviruses.
View Article and Find Full Text PDFmBio
September 2025
Department of Microbiology, Howard Taylor Ricketts Laboratory, The University of Chicago, Lemont, Illinois, USA.
infection is a frequent cause of sepsis in humans, a disease associated with high mortality and without specific intervention. Clumping factor A (ClfA) displayed on the bacterial surface plays a key role in promoting replication during invasive disease. Decades of research have pointed to a wide array of ligands engaged by ClfA.
View Article and Find Full Text PDFOncol Res
September 2025
Department of Biliary-Pancreatic Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy, largely driven by an immunosuppressive tumor microenvironment (TME) that facilitates tumor growth, immune escape, and resistance to therapy. Although immunotherapy-particularly immune checkpoint inhibitors (ICIs)-has transformed the therapeutic landscape by restoring T cell-mediated anti-tumor responses, their clinical benefit as monotherapy remains suboptimal. This limitation is primarily attributed to immunosuppressive components within the TME, including tumor-associated macrophages, regulatory T cells (Tregs), and myeloid-derived suppressor cells (MDSCs).
View Article and Find Full Text PDFACS Synth Biol
September 2025
Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada.
Imbalances in the mammalian gut are associated with acute and chronic conditions, and using engineered probiotic strains to deliver synthetic constructs to treat them is a promising strategy. However, high rates of mutational escape and genetic instability limit the effectiveness of biocontainment circuits needed for safe and effective use. Here, we describe STALEMATE (equence enngd ulti lyered geneic buffring), a dual-layered failsafe biocontainment strategy that entangles genetic sequences to create pseudoessentiality and buffer against mutations.
View Article and Find Full Text PDFSemin Oncol
September 2025
Departments of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, New Jersey, USA. Electronic address:
Chimeric antigen receptor (CAR) T-cell therapy has changed how we treat blood cancers but hasn't worked as well for solid tumors like pancreatic ductal adenocarcinoma (PDAC), mainly because these tumors are very aggressive and resistant to regular treatments. This review critically examines peer-reviewed studies to chart the evolution of immunotherapy in PDAC, emphasizing the unique barriers to effective CAR T-cell treatment and emerging strategies to overcome them. CAR T-cells that focus on tumor-related markers like mesothelin, HER2, and MUC1 have shown promise in early research models.
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