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Background: is a common enteric pathogen reported in human and many animals. But there are few reports of in nonhuman primates (NHPs). The aim of this study was to examine the prevalence and molecular characterization of in NHPs from Northern and Central China.
Results: A total of 299 specimens of NHPs were collected. The overall prevalence rate of was 9.4% (28/299) in NHPs by ribosomal internal transcribed spacer (ITS) amplification, including 10.0% (16/160) in captive NHPs and 8.6% (12/139) in wild NHPs. In captive NHPs, the infection rate was 9.1% in male, 11.5% in female. Infection rate in juvenile ITS (6.7%) was higher than in the adult ITS (5.6%). In different regions, infection rate in Hubei (14.7%) was higher than in Henan (7.6%) and Beijing (7.9%). Five genotypes were found, including 4 known genotypes (D, HND-Ⅰ, EbpC, SHW2) and a novel genotype named NHP1. Genotype D (8/28) and NHP1 (8/28) were the most prevalent, followed by EbpC (6/28), SHW2 (4/28), and HND-Ⅰ (2/28). All the 5 genotypes belonged to zoonotic Group1.
Conclusion: These findings could deepen our understanding of prevalence and genotype distribution in NHPs in China. Our study shows that NHPs may be the reservoir of zoonotic and might present a potential serious threat.
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http://dx.doi.org/10.1016/j.ijppaw.2022.02.001 | DOI Listing |
J Med Chem
September 2025
Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
New treatment strategies are required to combat the spread of drug-resistant malaria. The synthesis and preclinical evaluation of novel 3-hydroxy-propanamidines (HPAs), with modifications of the phenanthrene and the 4-fluorobenzamidine moieties, has yielded several analogs exhibiting excellent in vitro growth inhibition of drug-sensitive or resistant fresh clinical isolates and culture-adapted strains. No cytotoxicity in the human HepG2 cell line was observed, demonstrating notable parasite selectivity.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
School of Governance and Policy Science, The Chinese University of Hong Kong, Hong Kong, China (Hong Kong).
Background: Older adults are more vulnerable to severe consequences caused by seasonal influenza. Although seasonal influenza vaccination (SIV) is effective and free vaccines are available, the SIV uptake rate remained inadequate among people aged 65 years or older in Hong Kong, China. There was a lack of studies evaluating ChatGPT in promoting vaccination uptake among older adults.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520.
A frequent goal of phage biology is to quantify how well a phage kills a population of host bacteria. Unfortunately, traditional methods to quantify phage success can be time-consuming, limiting the throughput of experiments. Here, we use theory to show how the effects of phages on their hosts can be quantified using bacterial population dynamics measured in a high-throughput microplate reader (automated spectrophotometer).
View Article and Find Full Text PDFPLoS Pathog
September 2025
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz, California, United States of America.
The discovery of the endosymbiotic bacteria Wolbachia as an obligate symbiont of. filarial nematodes has led to antibiotic-based treatments for filarial diseases. While lab.
View Article and Find Full Text PDFPLoS One
September 2025
Chilean Invasive Mycosis Network, Santiago, Chile.
Background: Invasive mold diseases (IMDs) are a severe complication of immunocompromised subjects and an emerging problem among severely ill, apparently immunocompetent patients. The aim of this study was to describe the epidemiological and clinical features of IMDs in Chile.
Methods: Prospective study of IMD cases in children and adults from 11 reference hospitals in Chile from May 2019 to May 2021.