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Article Abstract
Background: Human cytochrome P450 (s) genes are essential in metabolising drugs. Due to their high polymorphism, population-specific studies are of great interest.
Aim: This research examined the six genes, including , , , , , and in the Kinh Vietnamese (KHV) for population-scale precision medicine.
Subjects And Methods: We processed data from a genomics database of 206 healthy and unrelated KHV individuals to calculate allele frequencies. First, we compared the genes of the KHV to six other populations retrieved from the 1000 Genomes Project. Second, we searched the PharmGBK database for drug-CYP interaction data to compile a drug dosage recommendation for the KHV.
Results: We observed the diverging trends in genetic variations of , , and in the KHV. Regarding phenotypic drug responses in the KHV, exhibited all metabolic phenotypes at a non-trivial frequency. In addition, metabolised drugs at a lower rate compared to the other five s.
Conclusion: This is the first large-scale study to investigate multiple genes in the KHV for precision medicine from a public health perspective. Differences found in the distributions of metabolizers for the KHV suggest careful prescriptions for and -metabolised drugs.
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| http://dx.doi.org/10.1080/03014460.2022.2052961 | DOI Listing |
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