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http://dx.doi.org/10.1111/1440-1681.13639 | DOI Listing |
Sleep Med Rev
August 2025
Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Viale Del Tirreno. 341/A/B/C, Calambrone, Pisa, 56128 Italy; Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Via Savi 10, 56126, Pisa, Italy.
Melatonin is known to be effective in improving sleep in pediatric patients affected by neurological and psychiatric conditions. However, no guidelines exist advising the most effective treatment schedule. This systematic review and meta-analysis aimed to identify the dose, time of administration and treatment duration associated with the maximal treatment efficacy.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
College of Food Science and Engineering, Jilin University, 130062, Changchun, PR China. Electronic address:
Active films displayed substantial prospects to maintain quality of tropical fruits during storage and transportation. This study developed multifunctional composite films loaded with melatonin/carvacrol nanoemulsions (MCNE) in guar gum/pullulan polysaccharide (GP) matrixes. The SEM analysis showed that MCNE was uniformly dispersed in GP film matrixes, and formed dense and continuous phase structure.
View Article and Find Full Text PDFProstaglandins Leukot Essent Fatty Acids
August 2025
Research Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, China; Dongguan No.7 People's Hospital (Dongguan Mental Health Center), Dongguan, China; Neuroscience Section, BGI Life Science Research Institute, Hangzhou, China. Elect
Background: Sleep disorders show comorbidity with depression and Alzheimer's disease (AD), especially in ageing. However, the neuroimmunological role of sleep deprivation (SD) as possible inducer to these conditions remains unknown. Omega-3 fatty acids (n-3 FAs) can improve depression and AD through anti-inflammation, up-regulating neurotrophins and normalizing neurotransmitters, while their therapeutic effects on sleep deprivation (SD)-induced changes in different ages requires investigation.
View Article and Find Full Text PDFChronobiol Int
September 2025
Chronobiology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, India.
Although delay-based shiftwork/jetlag schedules are often considered less disruptive than advances and are increasingly adopted in occupational settings, their long-term impact on physiological homeostasis remains underexplored. In this study, we investigated the consequences of repeated phase delays on circadian alignment, oxidative balance, endocrine function, and systemic inflammation in the diurnal rodent . Animals were kept either under a stable 12:12 hour light-dark (LD) cycle or subjected to a successive delay rotational shift (SDRS) schedule for 28 days.
View Article and Find Full Text PDFCurr Drug Discov Technol
August 2025
PSIT-Pranveer Singh Institute of Technology (Pharmacy), Bhauti-Kanpur, Uttar Pradesh, 209305, India.
Introduction: Basil, an indigenous medicinal herb, is widely used in traditional medicine for its therapeutic and cosmetic benefits. Its properties include reducing oxidative stress, increasing melatonin production, protecting cells from free radical damage, and protecting the skin. Basil can be incorporated into daily skincare routines to address various skin conditions and promote overall health.
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