Basil (Ocimum basilicum): A Natural Approach to Skin Care and Its Cosmeceutical Potential.

Introduction: Basil, an indigenous medicinal herb, is widely used in traditional medicine for its therapeutic and cosmetic benefits. Its properties include reducing oxidative stress, increasing melatonin production, protecting cells from free radical damage, and protecting the skin. Basil can be incorporated into daily skincare routines to address various skin conditions and promote overall health.

An Open-Source Normothermic Perfusion System Designed for Research Scientists.

The integration of ex vivo perfusion machines for human organs prior to transplantation has improved outcomes for recipients and increased organ availability while revealing novel avenues of investigation for translational medicine. However, these machines have limited availability for experimental modifications while presenting a significant upfront cost investment and prohibitive per-use cost to the research scientist. Furthermore, there is a significant need for improved pre-clinical models in biomedical research that allow for authentic interrogation of cellular processes in the multi-cellular organ setting.

Expression of IMPACT curtails metabolic plasticity and augments NK cell killing to abrogate metastatic growth.

Given the propensity of aggressive epithelial tumors to form hepatic metastases, we performed an in vivo cDNA screen using the mouse liver and KRASG12D/TP53R273H pancreatic cells to identify the RNA binding protein GCN1 as integral component of hepatic outgrowth. RNAi experiments reveal that GCN1 triggers the ISR to activate serine, folate, and methionine biosynthetic pathways together with amino acid transporters, which act in concert to facilitate acquisition of metabolites and to restore redox homeostasis. Alongside activation of the ISR, we found that GCN1 also functions in the nucleus where it interacts with HNRNPK to suppress the expression of MHC-I molecules, and natural killer (NK) ligands.

The Potential of Next-generation Multi-functional Nanoplatforms for Breast Cancer.

The next-generation nanoparticles overcome the drawbacks of early nanoplatforms by integrating multiple functions, such as drug delivery, controlled drug release, and combination therapy, into a single system. This study examines the biomedical applications of quantum dots, carbon nanotubes, superparamagnetic iron oxide nanoparticles, and layered double hydroxides for the delivery of breast cancer drugs. They are termed as "nextgeneration" nanoparticles, as they are advanced nanocarriers that offer a comprehensive and alternative approach towards breast cancer treatment, providing enhanced specificity and efficacy compared to their predecessors.

Endophytic Diaporthe citrichinensis as a new source to alleviate post-harvest fungal infections in apple (Malus x domestica Borkh.).

After harvesting, Apple is susceptible to being attacked by various fungal pathogens, rendering it unconsumable and further reducing its commercial value. To mitigate these losses, biocontrol strategies utilizing endophytic fungi are gaining momentum as effective alternatives to synthetic fungicides. In the present study, 155 endophytic fungi were isolated from various parts of Malus x domestica Borkh.

Efficacy of Different Obturating Materials - A Comparative Study.

Aim: To evaluate the efficacy of propolis and its combination products as an obturating material in comparison to Vitapex.

Materials And Methods: Propolis collected from the primary source was extracted using organic solvents and laboratory bio-assayed against Enterococcus faecalis to evaluate its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). For in-vivo studies, propolis efficacy was investigated in combination with zinc oxide and calcium hydroxide powder.

Design and development of ISFET-based portable microalgal biosensor using Chlorella sp. for the detection of organophosphorus pesticide.

The study is focused on fabricating a portable potentiometric biosensor using Chlorella sp. immobilized on TaO Ion-Sensitive Field Effect Transistor (ISFET) for detecting organophosphorus pesticides (OPPs). The developed biosensor detection mechanism is based on pesticide-induced inhibition of alkaline phosphatase enzyme activity, with a change in ascorbic acid production as a product signal.

Identifying Minimum Single Dose of Recombinant Human Hyaluronidase for In Vitro Dissolution of Twenty-Two Hyaluronic Acid Fillers.

Purpose: As the use of hyaluronic acid fillers continues to increase for clinical and aesthetic purposes, associated complications continue to rise as well. Excess hyaluronidase is often used to dissolve filler, which has its own set of adverse effects. This study analyzes 22 commercially available fillers to delineate the lowest single dose of recombinant human hyaluronidase (RHH) required to fully dissolve each filler within 6 hours across 3 trials.

Optic nerve and choroidal calcification in pediatric neurofibromatosis type 2.

We describe a teenage boy with gradually progressive blurred vision in right eye. He could appreciate hand motions in the right eye and 20/20 vision in the left eye. Ophthalmic examination revealed bilateral optic atrophy with yellow-white peri-papillary lesion in the right eye.

Infantile Epileptic Spasms Syndrome Due to Neonatal Hypoglycemic Brain Injury: A Retrospective Audit.

In this retrospective audit of 56 children with infantile epileptic spasms syndrome (IESS), neonatal hypoglycemic brain injury (NHBI) was the leading etiology (35.71%), followed by hypoxic ischemic encephalopathy (HIE) (25%). Other causes accounted for 30.

MBX V1.2: Accelerating Data-Driven Many-Body Molecular Dynamics Simulations.

The MBX software provides an advanced platform for molecular dynamics simulations, leveraging state-of-the-art MB-pol and MB-nrg data-driven many-body potential energy functions. Developed over the past decade, these potential energy functions integrate physics-based and machine-learned many-body terms trained on electronic structure data calculated at the "gold standard" coupled-cluster level of theory. Recent advancements in MBX have focused on optimizing its performance, resulting in the release of MBX v1.

Metastasis to jaw bones from renal cell carcinoma as the sole primary source: Systematic review.

Renal cell carcinoma (RCC) has been known for its high propensity of metastasis to unusual locations, and jaw bones (JBs) are one among those sites. The literature has reported several studies analyzing metastatic tumors to the oral region, but very little research work has been published to date to analyze solely JB metastasis (JBM) via RCC. The goal of this study was to examine the published cases of metastasis to JBs from RCC as the sole primary source till date.

Methodology for Safe and Secure AI in Diabetes Management.

The use of artificial intelligence (AI) in diabetes management is emerging as a promising solution to improve the monitoring and personalization of therapies. However, the integration of such technologies in the clinical setting poses significant challenges related to safety, security, and compliance with sensitive patient data, as well as the potential direct consequences on patient health. This article provides guidance for developers and researchers on identifying and addressing these safety, security, and compliance challenges in AI systems for diabetes management.

Probing the limits and capabilities of diffusion models for the anatomic editing of digital twins.

Numerical simulations of cardiovascular device deployment within digital twins of patient-specific anatomy can expedite and de-risk the device design process. Nonetheless, the exclusive use of patient-specific data constrains the anatomic variability that can be explored. We study how Latent Diffusion Models (LDMs) can edit digital twins to create digital siblings.

Current Status of the MB-pol Data-Driven Many-Body Potential for Predictive Simulations of Water Across Different Phases.

Developing a molecular-level understanding of the properties of water is central to numerous scientific and technological applications. However, accurately modeling water through computer simulations has been a significant challenge due to the complex nature of the hydrogen-bonding network that water molecules form under different thermodynamic conditions. This complexity has led to over five decades of research and many modeling attempts.

Removal of metals and assimilable organic carbon by activated carbon and reverse osmosis point-of-use water filtration systems.

Activated carbon (AC) systems and reverse osmosis (RO) systems are commonly used point-of-use (POU) water filtration systems for removing trace-level contaminants in tap water to protect human health. However, limited research has been done to evaluate their effectiveness in removing heavy metals like manganese (Mn) and uranium (U), or to assess the potential for undesired microbial growth within POU systems, which can reduce their treatment efficiency. This study aimed to systematically evaluate the removal of metals and assimilable organic carbon (AOC) in POU systems.

Jasmonate signaling modulates root growth by suppressing iron accumulation during ammonium stress.

Plants adapt to changing environmental conditions by adjusting their growth physiology. Nitrate (NO3-) and ammonium (NH4+) are the major inorganic nitrogen forms for plant uptake. However, high NH4+ inhibits plant growth, and roots undergo striking changes, such as inhibition of cell expansion and division, leading to reduced root elongation.

Myopic shift, refractive, and visual outcomes after 5 years of infantile cataract surgery: Our experience and review of literature.

Purpose: After infantile cataract surgery, axial elongation, induces a myopic shift that cannot be fully compensated by corneal flattening and the rate is unpredictable owing to the non-linear growth of the eye. The current prospective study assesses the myopic shift and visual outcomes in children undergoing cataract surgery in infancy over a follow-up period of 5 years.

Materials And Methods: A prospective study conducted at a tertiary eye care center to evaluate the five-year myopic shift, refractive and visual outcomes in infants, who underwent surgery for congenital cataract in infancy.