Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: Complex two-dimensional (2D) patterns of hyperfluorescent short-wave fundus autofluorescence (FAF) at the border of geographic atrophy (GA) can predict its expansion in patients with late non-exudative "dry" AMD. However, preclinical models do not phenocopy this important feature of disease. We sought to describe the spatiotemporal changes in hyperfluorescent FAF patterns that occur following acute oxidative stress, potentially in association with GA expansion.
Methods: Sprague Dawley rats (n = 54) received systemic sodium iodate (25-45 mg/kg, n = 90 eyes) or saline (n = 18 eyes) and underwent serial full fundus imaging by confocal scanning laser ophthalmoscopy, including blue FAF and delayed near-infrared analysis. Composite images of the fundus were assembled, and the 2D patterns were described qualitatively and quantitatively. A subset of eyes underwent tissue analysis, and four underwent optical coherence tomography (OCT) imaging.
Results: Reproducibly changing, complex patterns of hyperfluorescent FAF emerge at the borders of toxin-induced damage; however, in the absence of GA expansion, they percolate inward within the region of retinal pigment epithelium loss, evolving, maturing, and senescing in situ over time. Unexpectedly, the late FAF patterns most closely resemble the diffuse tricking form of clinical disease. A five-stage classification system is presented.
Conclusions: Longitudinal, full-fundus imaging of outer retinal atrophy in the rat eye identifies evolving, complex patterns of hyperfluorescent FAF that phenocopy aspects of disease.
Translational Relevance: This work provides a novel tool to assess hyperfluorescent FAF in association with progressive retinal atrophy, a therapeutic target in late AMD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914569 | PMC |
| http://dx.doi.org/10.1167/tvst.11.3.3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Severe Linear Retinal Burn from a Handheld Laser Pointer in a Pediatric Patient: A Case Report.
S D Med
September 2025
Department of Surgery, University of South Dakota Sanford School of Medicine.
Introduction: This paper presents a unique case of handheld laser-induced retinal injury associated with maculopathy and linear scotoma in a pediatric patient.
Results: A 12-year-old boy with no significant medical or ocular history presented with a scotoma in his right eye after using a handheld green laser pointer, labeled as 5 mW, 532 nm. Visual acuity was 20/20 in both eyes.
Case Report: A family of fluctuating cystoid macular edema caused by gene mutations.
Front Med (Lausanne)
August 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Cystoid macular edema (CME) is a common complication in various retinal disorders, often leading to significant central vision impairment. However, the underlying genetic causes and detailed clinical features in patients with fluctuating CME remain unclear. This retrospective, observational case series analyzed two patients from a single family with fluctuating CME, focusing on both clinical and genetic aspects.
View Article and Find Full Text PDFSpecific retinal vasculitis in HLA-A29 birdshot retinochoroiditis, distinguishing it from other causes of vasculitis: A pilot study.
Saudi J Ophthalmol
February 2025
Inflammatory and Retinal Eye Diseases, Centre for Ophthalmic Specialised Care, Lausanne, Switzerland.
Purpose: Human leukocyte antigen-A29 (HLA-A29) birdshot retinochoroiditis (BRC) is a noninfectious uveitis affecting independently the retina and the choroid. While the choroidal involvement is characterized by a stromal choroiditis, the retinal features of BRC were less well defined until a recent study determined a specific pattern of retinal involvement with seven features including profuse posterior retinal leakage, thick fluorescein angiography sheathing/staining, profuse disc hyperfluorescence, macular edema with foveal sparing, and circulatory arteriovenous pseudo delay. The aim of this study was to determine whether the specific pattern of retinal involvement was diagnostic for BRC distinguishing it from other causes of retinal vasculitis.
View Article and Find Full Text PDFAngioReport: dataset and baseline methods for fundus angiography report generation.
Br J Ophthalmol
July 2025
Department of Ophthalmology, College of Medicine, Rangsit University, Rajavithi Hospital, Bangkok, Thailand
Purpose: To develop an annotated fundus angiographic dataset, including fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA), and establish baseline methods for automatic report generation.
Methods: This retrospective study reviewed patients aged ≥18 years who underwent FFA or ICGA at Rajavithi Hospital, Thailand, between 1 January and 31 December 2019. A total of 55 361 de-identified images from 1691 patients (3179 eyes) were annotated by retinal specialists with detailed descriptions of the type, location, shape, size and pattern of abnormal fluorescence.
Fern-Like Pattern on Ultra-Widefield Fluorescein Angiography Across Various Uveitic Conditions.
Rom J Ophthalmol
May 2025
Department of Ophthalmology, Command Hospital (Eastern Command), Kolkata, India.
Objective: To investigate the occurrence and characteristics of the "Fern-like pattern" (FLP) on ultra-wide field fluorescein angiography (UWFA) across a variety of uveitic conditions, challenging the traditional association of FLP primarily with Behçet's disease (BD).
Methods: This observational study at a tertiary care centre in India analysed the UWFA images of 23 eyes from 12 patients diagnosed with BD, tubercular vasculitis, intermediate uveitis, Vogt‒Koyanagi‒Harada (VKH) syndrome, or exudative retinal detachment. Clinical and imaging data were reviewed to assess the presence and implications of FLP in these conditions.