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http://dx.doi.org/10.1111/resp.14238 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Cancer Research Center of Marseille: Team DNA Damage and Genome Instability|CNRS, Inserm, Institut Paoli-Calmettes, Aix Marseille Université, Marseille 13009, France.
Following encounter with an unrepaired DNA lesion, replication is halted and can restart downstream of the lesion leading to the formation of a single-stranded DNA (ssDNA) gap. To complete replication, this ssDNA gap is filled in by one of the two lesion tolerance pathways: the error-prone Translesion Synthesis (TLS) or the error-free Homology Directed Gap Repair (HDGR). In the present work, we evidence a role for the RecBC complex distinct from its canonical function in homologous recombination at DNA double strand breaks.
View Article and Find Full Text PDFRSC Chem Biol
September 2025
Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia PA USA.
The bacterial DNA damage (SOS) response promotes DNA repair, DNA damage tolerance, and survival in the setting of genotoxic stress, including stress induced by antibiotics. In , translesion DNA synthesis can be fulfilled by Y-family DNA polymerases, including DNA polymerase IV (DinB). DinB features a more open active site and lacks proofreading ability, promoting error-prone replication.
View Article and Find Full Text PDFCureus
August 2025
Dermatology, Pierre Fabre Dermocosmetics Brazil, São Paulo, BRA.
Background In acne-prone skin, the loss of homeostasis leads to aberrant epithelial differentiation, promoting the formation of microcomedones. The maintenance of sebaceous stem cell homeostasis has emerged as a new therapeutic target in acne management. Objective: The aim of this study is to evaluate the efficacy, tolerability, and safety of a topical formulation combining retinaldehyde, glycolic acid, and Silybum marianum fruit extract for the treatment of acne vulgaris.
View Article and Find Full Text PDFFront Pediatr
August 2025
Department of Pediatrics, Anqing Municipal Hospital, Anqing, Anhui, China.
Background: The causes of children aerophagia are complex, and the treatment methods are diverse. Moreover, it is prone to recurrent attacks. Simethicone oil, as a safe and new type of drug, can be used for treatment.
View Article and Find Full Text PDFPhysiol Mol Biol Plants
July 2025
Soil Bacteriology Section, Agricultural Biotechnology Research Institute, Ayub Agricultural Research Institute, Faisalabad, Pakistan.
Unlabelled: Drought stress substantially threatens global food security. To cope with this, a field-based trial was performed to examine the influence of PGPRs/microbial consortia & ) and kinetin on the maize under full irrigation and 50% drought. The results of biochemical features of bacteria revealed positive for phosphorus, and zinc solubilization with great capacity to battle stress circumstances owing (ACC deaminase, Indole 3 Acetic acid IAA, and siderophore) production.
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