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The interactions between biomembranes and particles are key to many applications, but the lack of controllable model systems to study them limits the progress in their research. Here, we describe how Janus polystyrene microparticles, half coated with iron, can be partially engulfed by artificial cells, namely giant vesicles, with the goals to control and investigate their adhesion and degree of encapsulation. The interaction between the Janus particles and these model cell membrane systems is mediated by electrostatic charge, offering a further mode of modulation in addition to the iron patches. The ferromagnetic particle coatings also enable manipulation and transport of the vesicles by magnetic fields.
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http://dx.doi.org/10.1039/d1cc07026f | DOI Listing |
Macromol Biosci
September 2025
IMEM-BRT Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, Barcelona, Spain.
This study investigates a multifunctional hydrogel system integrating carboxymethyl cellulose (CMC) in a 3D-printed limonene (LIM) scaffold coated with poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS). The system allows to enhance wound healing, prevent infections, and monitor the healing progress. CMC is crosslinked with citric acid (CA) to form the hydrogel matrix (CMC-CA), while the 3D-printed limonene (LIM) scaffold is embedded within the hydrogel to provide mechanical support.
View Article and Find Full Text PDFACS Nano
September 2025
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Key Laboratory of Innovation and Transformation of Advanced Medical Devices of Ministry of Industry and Information Technology, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Dev
Hyperglycemia-induced oxidative stress and inflammation critically impair diabetic bone defect repair. Here, a radially oriented microchannel scaffold (D-GSH@QZ) was developed via a directional freezing technique integrated with photo-cross-linking strategies. The scaffold was fabricated from gelatin methacryloyl, silk fibroin methacryloyl, and nanohydroxyapatite (HAp) to mimic the natural bone matrix, while incorporating quercetin-loaded ZIF-8 nanoparticles (Qu@ZIF-8) for pathological microenvironment modulation.
View Article and Find Full Text PDFFront Microbiol
August 2025
Department of Microbiology and Botany, Faculty of Biology, University of Bucharest, Bucharest, Romania.
Introduction: This study evaluates two innovative protective treatments for wooden cultural heritage objects vulnerable to biodeterioration. The first involves polyacrylic resin solutions embedded with silver nanoparticles (AgNPs), while the second uses the siloxane-based coupling agent 3-mercaptopropyltrimethoxysilane (3-MPTMS) to enhance AgNP adhesion to wood surfaces.
Methods: Antimicrobial, anti-biofilm, and anti-metabolic activities were assessed using both qualitative and quantitative assays against biodeteriogenic strains (, and ).
NPJ Biomed Innov
September 2025
Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON N6A 5B9 Canada.
We report a synthetic tetrahedral DNA nanocarrier (TDN) for treating bone defects and methicillin-resistant (MRSA) infection using in vitro studies. We successfully synthesized TDNs and demonstrated their excellent cytocompatibility with blood cells and immune cells. Zoledronic acid-loaded TDN displayed increased efficacy compared to free drugs in regulating bone remodeling, while vancomycin-loaded TDN showed an increased antibacterial effect against MRSA.
View Article and Find Full Text PDFRSC Adv
August 2025
University of Coimbra, CEMMPRE, ARISE, Department of Mechanical Engineering Rua Luís Reis Santos Coimbra 3030-788 Portugal.
This study addresses the growing need for sustainable and multifunctional materials by developing novel polycaprolactone (PCL)/chitosan (CS)/zirconium dioxide (ZrO) nanocomposite films. While PCL and CS offer biocompatibility and biodegradability, their combined use presents limitations for advanced applications requiring specific functional features. The incorporation of ZrO nanoparticles aims to overcome these limitations and create materials with enhanced mechanical, electrical, optical, and antibacterial properties.
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