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Objective: To examine associations between sleep-disordered breathing (SDB) and executive/attentional function in pediatric sickle cell disease (SCD).
Methods: Sixty youth with SCD ages 8-18 years and caregivers completed the Pediatric Sleep Questionnaire (PSQ), Delis Kaplan Executive Function System Trail Making Test (DKEFS TMT), Psychomotor Vigilance Test (PVT), and the Behavior Rating Inventory Of Executive Function, Second Edition (BRIEF-2) Parent Report.
Results: The PSQ significantly predicted the BRIEF-2 Parent Report, (1, 58) = 44.64, < .001, R = 0.44, f = 0.77.
Conclusions: Sleep-disordered breathing symptoms may predict informant-rated executive dysfunction in pediatric SCD, but not performance-based executive function.
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http://dx.doi.org/10.1080/87565641.2022.2038601 | DOI Listing |
Cancer Rep (Hoboken)
September 2025
Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Centre of Soochow University, Suzhou, Jiangsu, China.
Background: Epigenetic regulation significantly affects immune responses in lung adenocarcinoma (LUAD). However, the role of RNA N6-methyladenosine (m6A) modification, especially in obstructive sleep apnea-hypopnea syndrome (OSAHS) within LUAD, is not well understood.
Methods: This study examined m6A modification patterns in 973 LUAD patients using 23 regulatory genes.
Sleep Med Rev
August 2025
Department of Pediatrics, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Pediatric obstructive sleep apnea (OSA) is a common yet often underdiagnosed condition, partly due to limited access to polysomnography. Mandibular jaw movement (MJM) analysis offers a promising alternative to conventional home sleep apnea testing in children, capturing the dynamic interactions between respiratory drive and upper airway musculature, enabling accurate identification of, and critical insights into, sleep-disordered breathing events. This technical and practical review provides a structured framework for understanding and interpreting MJM signals during sleep in pediatric patients.
View Article and Find Full Text PDFCerebellum
September 2025
Department of Neurology, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Multiple system atrophy (MSA) is a progressive, adult-onset neurodegenerative disorder involving autonomic failure, cerebellar ataxia, and parkinsonism. Patients often require invasive interventions, such as gastrostomy or tracheostomy, and sudden death is common. This study aimed to elucidate patterns of invasive treatment and identify risk factors for tracheostomy or sudden death within 5 years of onset.
View Article and Find Full Text PDFSleep Med Clin
September 2025
Department of Neurology and Stroke, St. Adalbert Hospital, Gdańsk, Poland; Division of Neurological and Psychiatric Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland. Electronic address:
Neurodegeneration in dementia with Lewy bodies affects all crucial networks responsible for sleep control and as a result, the sleep cycle is heavily disturbed. Certain sleep syndromes such as rapid eye movement sleep behavior disorder and hypersomnia are particularly common and characteristic features of the disease, but patients also suffer from insomnia, sleep disordered breathing, movement disorders during sleep, or nighttime urinary dysfunction. Several treatment options are available nowadays; however, more trials on efficacy and safety in this population are still needed.
View Article and Find Full Text PDFAm J Hum Genet
September 2025
Department of Medicine, Harvard Medical School, Boston, MA, USA; CardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Bosto
Strong sex differences exist in sleep phenotypes and also cardiovascular diseases (CVDs). However, sex-specific causal effects of sleep phenotypes on CVD-related outcomes have not been thoroughly examined. Mendelian randomization (MR) analysis is a useful approach for estimating the causal effect of a risk factor on an outcome of interest when interventional studies are not available.
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